Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM486367
Substrate
n/a
Meas. Tech.
DGAT2 Enzymatic Activity Assay
IC50
692±n/a nM
Citation
 Shen, D; Graham, TH; Jiang, J; Ding, F; Tudge, C Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent  US10947222 Publication Date 3/16/2021 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM486367
Synonyms:
3-(2-chlorophenyl)-1-(4-fluorophenyl)- 2-methyl-N-(3-methyl-1,1- dioxidotetrahydrothiophen-3-yl)-1H- indole-6-carboxamide (Enantiomer B) | US10947222, Example 8-B
Type:
Small organic molecule
Emp. Form.:
C27H24ClFN2O3S
Mol. Mass.:
511.007
SMILES:
Cc1c(-c2ccccc2Cl)c2ccc(cc2n1-c1ccc(F)cc1)C(=O)N[C@@]1(C)CCS(=O)(=O)C1 |r,wU:27.30,wD:27.31,(6.89,.73,;5.35,.73,;4.45,1.98,;4.92,3.44,;3.89,4.59,;4.37,6.05,;5.87,6.37,;6.9,5.23,;6.43,3.76,;7.46,2.62,;2.98,1.5,;1.65,2.27,;.31,1.5,;.31,-.04,;1.65,-.81,;2.98,-.04,;4.45,-.51,;4.92,-1.98,;3.89,-3.12,;4.37,-4.59,;5.87,-4.91,;6.35,-6.37,;6.9,-3.76,;6.43,-2.3,;-1.02,-.81,;-.62,-2.3,;-2.35,-.04,;-3.69,-.81,;-4.09,.68,;-3.85,-2.34,;-5.35,-2.66,;-6.12,-1.33,;-7.46,-.56,;-7.46,-2.1,;-5.09,-.18,)|
Structure:
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