Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM486425
Substrate
n/a
Meas. Tech.
DGAT2 Enzymatic Activity Assay
IC50
502±n/a nM
Citation
 Shen, D; Graham, TH; Jiang, J; Ding, F; Tudge, C Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent  US10947222 Publication Date 3/16/2021 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM486425
Synonyms:
3-(3,5-dimethylisoxazol-4-yl)-N- (1,1-dioxidotetrahydrothiophen-3- yl)-1-(4-fluorophenyl)-1H-indole- 6-carboxamide (racemic) | US10947222, Example 53
Type:
Small organic molecule
Emp. Form.:
C24H22FN3O4S
Mol. Mass.:
467.513
SMILES:
Cc1noc(C)c1-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1 |(7.55,3.23,;6.3,4.14,;6.3,5.68,;4.83,6.15,;3.93,4.91,;2.39,4.91,;4.83,3.66,;4.36,2.2,;5.26,.95,;4.36,-.29,;4.83,-1.76,;6.34,-2.08,;6.82,-3.54,;5.79,-4.69,;6.26,-6.15,;4.28,-4.37,;3.8,-2.9,;2.89,.18,;1.56,-.59,;.23,.18,;.23,1.72,;1.56,2.49,;2.89,1.72,;-1.11,-.59,;-1.11,-2.13,;-2.44,.18,;-3.77,-.59,;-3.94,-2.12,;-5.44,-2.44,;-6.21,-1.11,;-7.55,-.34,;-7.55,-1.88,;-5.18,.04,)|
Structure:
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