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Target
Tyrosine-protein kinase SYK [342-635]
Ligand
BDBM375946
Substrate
n/a
Meas. Tech.
Syk Kinase Test
IC50
12.3±n/a nM
Citation
 Dahmann, G; Hoffmann, M; Klicic Badoux, J; Lamb, DJ; McCarthy, C; Napier, SC; Parrish, K; Scott, J; Fitzgerald, JL; Walker, E Heteroaryl SYK inhibitors US Patent  US10947243 Publication Date 3/16/2021 
Target
Name:
Tyrosine-protein kinase SYK [342-635]
Synonyms:
KSYK_HUMAN | SYK | SYK (aa 342-635)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34105.36
Organism:
Homo sapiens (Human)
Description:
P43405[342-635]
Residue:
294
Sequence:
PMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM375946
Synonyms:
US10947243, Example 12 | US9914735, Example 12
Type:
Small organic molecule
Emp. Form.:
C27H36N8O3
Mol. Mass.:
520.6265
SMILES:
C[C@@H](Oc1nc(cc2nn(C)cc12)-c1cnn(c1)[C@H]1CC[C@@H](CC1)N1CCN(C)C(=O)C1)[C@H]1CNC(=O)C1 |r,wU:32.36,1.0,21.27,wD:18.20,(2.24,5.88,;.9,6.65,;-.43,5.88,;-.43,4.34,;.9,3.57,;.9,2.03,;-.43,1.26,;-1.76,2.03,;-3.23,1.55,;-4.13,2.8,;-5.67,2.8,;-3.23,4.04,;-1.76,3.57,;2.24,1.26,;3.78,1.26,;4.25,-.21,;3.01,-1.11,;1.76,-.21,;3.01,-2.65,;1.67,-3.42,;1.67,-4.96,;3.01,-5.73,;4.34,-4.96,;4.34,-3.42,;3.01,-7.27,;1.67,-8.04,;1.67,-9.58,;3.01,-10.35,;3.01,-11.89,;4.34,-9.58,;5.67,-10.35,;4.34,-8.04,;.9,8.19,;-.34,9.09,;.13,10.56,;1.67,10.56,;2.44,11.89,;2.15,9.09,)|
Structure:
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