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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487470
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
5500±n/a nM
Citation
 Lee, T; Kim, K; Christov, PP; Belmar, J; Burke, JP; Olejniczak, ET; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487470
Synonyms:
US10954193, Example 110
Type:
Small organic molecule
Emp. Form.:
C33H36ClN5O3
Mol. Mass.:
586.124
SMILES:
Cc1nn(Cc2ncccn2)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(CCC(O)=O)c12 |(-.2,-1.67,;-1.54,-2.44,;-2.01,-3.9,;-3.55,-3.9,;-4.32,-5.23,;-5.86,-5.23,;-6.63,-3.9,;-8.17,-3.9,;-8.94,-5.23,;-8.17,-6.57,;-6.63,-6.57,;-4.03,-2.44,;-5.36,-1.67,;-2.78,-1.53,;-2.78,.01,;-4.12,.78,;-4.12,2.32,;-2.78,3.09,;-1.45,2.32,;.02,2.8,;.42,4.28,;1.9,4.68,;2.3,6.17,;3.79,6.57,;4.88,5.48,;4.48,3.99,;5.57,2.9,;5.17,1.41,;7.06,3.3,;8.14,2.21,;7.45,4.79,;8.94,5.19,;6.37,5.88,;.92,1.55,;2.46,1.55,;.02,.3,;.42,-1.18,;1.9,-1.58,;2.3,-3.07,;3.79,-3.47,;1.21,-4.16,;-1.45,.78,)|
Structure:
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