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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487498
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
400±n/a nM
Citation
 Lee, T; Kim, K; Christov, PP; Belmar, J; Burke, JP; Olejniczak, ET; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487498
Synonyms:
US10954193, Example 69
Type:
Small organic molecule
Emp. Form.:
C27H30ClN3O3
Mol. Mass.:
479.998
SMILES:
Cc1n[nH]c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(CC(O)=O)c12 |(-1.99,-3,;-3.33,-3.77,;-3.8,-5.23,;-5.34,-5.23,;-5.82,-3.77,;-7.15,-3,;-4.57,-2.86,;-4.57,-1.32,;-5.91,-.55,;-5.91,.99,;-4.57,1.76,;-3.24,.99,;-1.77,1.46,;-1.37,2.95,;.11,3.35,;.51,4.84,;2,5.23,;3.09,4.14,;2.69,2.66,;3.78,1.57,;3.38,.08,;5.27,1.97,;6.35,.88,;5.66,3.45,;7.15,3.85,;4.58,4.54,;-.87,.22,;.67,.22,;-1.77,-1.03,;-1.3,-2.49,;.21,-2.81,;.68,-4.28,;1.24,-1.67,;-3.24,-.55,)|
Structure:
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