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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487503
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
200±n/a nM
Citation
 Lee, T; Kim, K; Christov, PP; Belmar, J; Burke, JP; Olejniczak, ET; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487503
Synonyms:
US10954193, Example 30
Type:
Small organic molecule
Emp. Form.:
C34H36ClN3O4
Mol. Mass.:
586.12
SMILES:
Cc1c(c(COc2ccccc2)nn1C)-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)cn(CCC(O)=O)c12 |(-1.37,-2.33,;-2.7,-3.1,;-3.95,-2.2,;-5.2,-3.1,;-6.68,-2.7,;-7.77,-3.79,;-9.26,-3.39,;-9.58,-1.89,;-11.05,-1.41,;-12.19,-2.44,;-11.87,-3.95,;-10.4,-4.42,;-4.72,-4.57,;-3.18,-4.57,;-2.41,-5.9,;-3.95,-.66,;-5.28,.11,;-5.28,1.65,;-3.95,2.42,;-2.62,1.65,;-1.15,2.13,;-.75,3.62,;.73,4.01,;1.13,5.5,;2.62,5.9,;3.71,4.81,;3.31,3.32,;4.4,2.24,;4,.75,;5.89,2.63,;6.98,1.55,;6.29,4.12,;7.77,4.52,;5.2,5.21,;-.25,.88,;-1.15,-.36,;-.75,-1.85,;.73,-2.25,;1.82,-1.16,;3.31,-1.56,;1.42,.33,;-2.62,.11,)|
Structure:
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