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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487530
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
 Lee, T; Kim, K; Christov, PP; Belmar, J; Burke, JP; Olejniczak, ET; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487530
Synonyms:
US10954193, Example 74
Type:
Small organic molecule
Emp. Form.:
C28H32ClN3O3
Mol. Mass.:
494.025
SMILES:
Cc1n[nH]c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(CCC(O)=O)c12 |(-1.99,-2.87,;-3.33,-3.64,;-3.8,-5.1,;-5.34,-5.1,;-5.82,-3.64,;-7.15,-2.87,;-4.57,-2.73,;-4.57,-1.19,;-5.91,-.42,;-5.91,1.12,;-4.57,1.89,;-3.24,1.12,;-1.77,1.59,;-1.37,3.08,;.11,3.48,;.51,4.96,;2,5.36,;3.09,4.27,;2.69,2.79,;3.78,1.7,;3.38,.21,;5.27,2.1,;6.35,1.01,;5.66,3.58,;7.15,3.98,;4.58,4.67,;-.87,.35,;.67,.35,;-1.77,-.9,;-1.37,-2.39,;.11,-2.79,;.51,-4.27,;2,-4.67,;-.58,-5.36,;-3.24,-.42,)|
Structure:
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