Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487543
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
Lee, T; Kim, K; Christov, PP; Belmar, J; Burke, JP; Olejniczak, ET; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent US10954193 Publication Date 3/23/2021
More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Inhibitor
Name:
BDBM487543
Synonyms:
US10954193, Example 87
Type:
Small organic molecule
Emp. Form.:
C36H41ClN4O4S
Mol. Mass.:
661.253
SMILES:
CCn1nc(C)c(c1C)-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(CCC(=O)NS(=O)(=O)c3ccccc3)c12 |(-5.54,-6.57,;-6.31,-5.23,;-5.54,-3.9,;-4,-3.9,;-3.53,-2.44,;-2.19,-1.67,;-4.77,-1.53,;-6.02,-2.44,;-7.35,-1.67,;-4.77,.01,;-6.1,.78,;-6.1,2.32,;-4.77,3.09,;-3.44,2.32,;-1.97,2.8,;-1.57,4.28,;-.09,4.68,;.31,6.17,;1.8,6.57,;2.89,5.48,;2.49,3.99,;3.58,2.9,;3.18,1.41,;5.07,3.3,;6.16,2.21,;5.46,4.79,;6.95,5.19,;4.38,5.88,;-1.07,1.55,;.47,1.55,;-1.97,.3,;-1.57,-1.18,;-.09,-1.58,;.31,-3.07,;-.78,-4.16,;1.8,-3.47,;2.89,-2.38,;1.8,-1.29,;3.29,-.89,;4.38,-2.78,;4.77,-4.27,;6.26,-4.66,;7.35,-3.58,;6.95,-2.09,;5.46,-1.69,;-3.44,.78,)|