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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487544
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
 Lee, T; Kim, K; Christov, PP; Belmar, J; Burke, JP; Olejniczak, ET; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487544
Synonyms:
US10954193, Example 88
Type:
Small organic molecule
Emp. Form.:
C36H41ClN4O4S
Mol. Mass.:
661.253
SMILES:
Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(CCC(=O)NS(=O)(=O)Cc3ccccc3)c12 |(-2.7,-2.33,;-4.04,-3.1,;-4.51,-4.57,;-6.05,-4.57,;-6.82,-5.9,;-6.53,-3.1,;-7.86,-2.33,;-5.28,-2.2,;-5.28,-.66,;-6.62,.11,;-6.62,1.65,;-5.28,2.42,;-3.95,1.65,;-2.49,2.13,;-2.09,3.62,;-.6,4.01,;-.2,5.5,;1.29,5.9,;2.38,4.81,;1.98,3.32,;3.07,2.24,;2.67,.75,;4.55,2.63,;5.64,1.55,;4.95,4.12,;6.44,4.52,;3.86,5.21,;-1.58,.88,;-.04,.88,;-2.49,-.36,;-2.09,-1.85,;-.6,-2.25,;-.2,-3.74,;-1.29,-4.83,;1.29,-4.14,;2.38,-3.05,;1.29,-1.96,;2.77,-1.56,;3.86,-3.45,;5.2,-2.68,;6.53,-3.45,;7.86,-2.68,;7.86,-1.14,;6.53,-.37,;5.2,-1.14,;-3.95,.11,)|
Structure:
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