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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487545
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
 Lee, T; Kim, K; Christov, PP; Belmar, J; Burke, JP; Olejniczak, ET; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487545
Synonyms:
US10954193, Example 89
Type:
Small organic molecule
Emp. Form.:
C39H41ClN4O4S
Mol. Mass.:
697.285
SMILES:
Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(CCC(=O)NS(=O)(=O)c3ccc4ccccc4c3)c12 |(-3.48,-2.33,;-4.81,-3.1,;-5.29,-4.57,;-6.83,-4.57,;-7.6,-5.9,;-7.31,-3.1,;-8.64,-2.33,;-6.06,-2.2,;-6.06,-.66,;-7.39,.11,;-7.39,1.65,;-6.06,2.42,;-4.73,1.65,;-3.26,2.13,;-2.86,3.62,;-1.37,4.01,;-.98,5.5,;.51,5.9,;1.6,4.81,;1.2,3.32,;2.29,2.24,;1.89,.75,;3.78,2.63,;4.87,1.55,;4.18,4.12,;5.66,4.52,;3.09,5.21,;-2.36,.88,;-.82,.88,;-3.26,-.36,;-2.86,-1.85,;-1.37,-2.25,;-.98,-3.74,;-2.07,-4.83,;.51,-4.14,;1.6,-3.05,;.51,-1.96,;2,-1.56,;3.09,-3.45,;3.49,-4.93,;4.97,-5.33,;6.06,-4.24,;7.55,-4.64,;8.64,-3.55,;8.24,-2.06,;6.75,-1.67,;5.66,-2.75,;4.18,-2.36,;-4.73,.11,)|
Structure:
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