Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487547
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
 Lee, TKim, KChristov, PPBelmar, JBurke, JPOlejniczak, ETFesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487547
Synonyms:
US10954193, Example 91
Type:
Small organic molecule
Emp. Form.:
C35H38ClN5O6S
Mol. Mass.:
692.224
SMILES:
Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(CCC(=O)NS(=O)(=O)c3ccccc3[N+]([O-])=O)c12 |(-2.19,-1.53,;-3.53,-2.3,;-4,-3.76,;-5.54,-3.76,;-6.31,-5.1,;-6.02,-2.3,;-7.35,-1.53,;-4.77,-1.39,;-4.77,.15,;-6.1,.92,;-6.1,2.46,;-4.77,3.23,;-3.44,2.46,;-1.97,2.93,;-1.57,4.42,;-.09,4.82,;.31,6.31,;1.8,6.7,;2.89,5.62,;2.49,4.13,;3.58,3.04,;3.18,1.55,;5.07,3.44,;6.16,2.35,;5.46,4.93,;6.95,5.32,;4.38,6.01,;-1.07,1.69,;.47,1.69,;-1.97,.44,;-1.57,-1.05,;-.09,-1.45,;.31,-2.93,;-.78,-4.02,;1.8,-3.33,;2.89,-2.24,;1.8,-1.15,;3.29,-.75,;4.38,-2.64,;5.46,-1.55,;6.95,-1.95,;7.35,-3.44,;6.26,-4.53,;4.74,-4.17,;3.65,-5.26,;2.16,-4.86,;4.04,-6.74,;-3.44,.92,)|
Structure:
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