Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487552
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
 Lee, TKim, KChristov, PPBelmar, JBurke, JPOlejniczak, ETFesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487552
Synonyms:
US10954193, Example 96
Type:
Small organic molecule
Emp. Form.:
C34H38ClN5O4S
Mol. Mass.:
648.215
SMILES:
Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(CCC(=O)NS(=O)(=O)c3ccncc3)c12 |(-2.19,-2.33,;-3.53,-3.1,;-4,-4.57,;-5.54,-4.57,;-6.31,-5.9,;-6.02,-3.1,;-7.35,-2.33,;-4.77,-2.2,;-4.77,-.66,;-6.1,.11,;-6.1,1.65,;-4.77,2.42,;-3.44,1.65,;-1.97,2.13,;-1.57,3.62,;-.09,4.01,;.31,5.5,;1.8,5.9,;2.89,4.81,;2.49,3.32,;3.58,2.24,;3.18,.75,;5.07,2.63,;6.16,1.55,;5.46,4.12,;6.95,4.52,;4.38,5.21,;-1.07,.88,;.47,.88,;-1.97,-.36,;-1.57,-1.85,;-.09,-2.25,;.31,-3.74,;-.78,-4.83,;1.8,-4.14,;2.89,-3.05,;1.8,-1.96,;3.29,-1.56,;4.38,-3.45,;4.77,-4.93,;6.26,-5.33,;7.35,-4.24,;6.95,-2.75,;5.46,-2.36,;-3.44,.11,)|
Structure:
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