Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487553
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
Lee, T; Kim, K; Christov, PP; Belmar, J; Burke, JP; Olejniczak, ET; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent US10954193 Publication Date 3/23/2021
More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Inhibitor
Name:
BDBM487553
Synonyms:
US10954193, Example 98
Type:
Small organic molecule
Emp. Form.:
C33H34ClN3O3
Mol. Mass.:
556.094
SMILES:
Cc1n[nH]c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(Cc3ccc(cc3)C(O)=O)c12 |(-1.99,-2.82,;-3.33,-3.59,;-3.8,-5.05,;-5.34,-5.05,;-5.82,-3.59,;-7.15,-2.82,;-4.57,-2.68,;-4.57,-1.14,;-5.91,-.37,;-5.91,1.17,;-4.57,1.94,;-3.24,1.17,;-1.77,1.64,;-1.37,3.13,;.11,3.53,;.51,5.02,;2,5.42,;3.09,4.33,;2.69,2.84,;3.78,1.75,;3.38,.26,;5.27,2.15,;6.35,1.06,;5.66,3.64,;7.15,4.04,;4.58,4.73,;-.87,.4,;.67,.4,;-1.77,-.85,;-1.37,-2.33,;.11,-2.73,;.51,-4.22,;2,-4.62,;3.14,-3.55,;2.69,-2.04,;1.2,-1.64,;4.63,-3.94,;5.03,-5.43,;5.72,-2.86,;-3.24,-.37,)|