Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487560
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
 Lee, TKim, KChristov, PPBelmar, JBurke, JPOlejniczak, ETFesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487560
Synonyms:
US10954193, Example 106
Type:
Small organic molecule
Emp. Form.:
C33H40ClN3O4
Mol. Mass.:
578.141
SMILES:
Cc1nn(CC2CCOC2)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(CCC(O)=O)c12 |(-.56,-1.71,;-1.89,-2.48,;-2.37,-3.94,;-3.91,-3.94,;-4.68,-5.28,;-6.22,-5.28,;-7.12,-6.52,;-8.59,-6.05,;-8.59,-4.51,;-7.12,-4.03,;-4.38,-2.48,;-5.72,-1.71,;-3.14,-1.57,;-3.14,-.03,;-4.47,.74,;-4.47,2.28,;-3.14,3.05,;-1.8,2.28,;-.34,2.75,;.06,4.24,;1.55,4.64,;1.95,6.13,;3.43,6.52,;4.52,5.43,;4.12,3.95,;5.21,2.86,;4.81,1.37,;6.7,3.26,;7.79,2.17,;7.1,4.74,;8.59,5.14,;6.01,5.83,;.57,1.51,;2.11,1.51,;-.34,.26,;.06,-1.23,;1.55,-1.63,;1.95,-3.11,;3.43,-3.51,;.86,-4.2,;-1.8,.74,)|
Structure:
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