Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487566
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
 Lee, TKim, KChristov, PPBelmar, JBurke, JPOlejniczak, ETFesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487566
Synonyms:
US10954193, Example 120
Type:
Small organic molecule
Emp. Form.:
C28H29ClF3N3O3
Mol. Mass.:
547.996
SMILES:
Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(n(CC(O)=O)c12)C(F)(F)F |(-1.99,-2.33,;-3.33,-3.1,;-3.8,-4.57,;-5.34,-4.57,;-6.11,-5.9,;-5.82,-3.1,;-7.15,-2.33,;-4.57,-2.2,;-4.57,-.66,;-5.91,.11,;-5.91,1.65,;-4.57,2.42,;-3.24,1.65,;-1.77,2.13,;-1.37,3.62,;.11,4.01,;.51,5.5,;2,5.9,;3.09,4.81,;2.69,3.32,;3.78,2.24,;3.38,.75,;5.27,2.63,;6.35,1.55,;5.66,4.12,;7.15,4.52,;4.58,5.21,;-.87,.88,;-1.77,-.36,;-1.3,-1.83,;.21,-2.15,;.68,-3.61,;1.24,-1,;-3.24,.11,;.67,.88,;2.21,.88,;.67,2.42,;.67,-.66,)|
Structure:
Search PDB for entries with ligand similarity: