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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487568
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
 Lee, T; Kim, K; Christov, PP; Belmar, J; Burke, JP; Olejniczak, ET; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487568
Synonyms:
US10954193, Example 122
Type:
Small organic molecule
Emp. Form.:
C34H32Cl2F3N3O3
Mol. Mass.:
658.537
SMILES:
Cc1nn(C)c(C)c1-c1c(Cl)ccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(n(Cc3cccc(c3)C(O)=O)c12)C(F)(F)F |(-1.95,-1.93,;-3.28,-2.7,;-3.76,-4.16,;-5.3,-4.16,;-6.07,-5.5,;-5.77,-2.7,;-7.11,-1.93,;-4.53,-1.79,;-4.53,-.25,;-5.86,.52,;-7.2,-.25,;-5.86,2.06,;-4.53,2.83,;-3.19,2.06,;-1.73,2.53,;-1.33,4.02,;.16,4.42,;.55,5.91,;2.04,6.31,;3.13,5.22,;2.73,3.73,;3.82,2.64,;3.42,1.15,;5.31,3.04,;6.4,1.95,;5.71,4.53,;7.2,4.93,;4.62,5.62,;-.82,1.29,;-1.73,.04,;-1.33,-1.45,;.16,-1.84,;1.25,-.75,;2.73,-1.15,;3.13,-2.64,;2.06,-3.78,;.55,-3.33,;2.46,-5.27,;1.37,-6.36,;3.94,-5.67,;-3.19,.52,;.72,1.29,;2.26,1.29,;.72,2.83,;.72,-.25,)|
Structure:
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