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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487571
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
 Lee, T; Kim, K; Christov, PP; Belmar, J; Burke, JP; Olejniczak, ET; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487571
Synonyms:
US10954193, Example 125
Type:
Small organic molecule
Emp. Form.:
C35H39ClN4O4S
Mol. Mass.:
647.227
SMILES:
Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(Cc3cccc(c3)C(=O)NS(C)(=O)=O)c12 |(-1.99,-1.93,;-3.33,-2.7,;-3.8,-4.16,;-5.34,-4.16,;-6.11,-5.5,;-5.82,-2.7,;-7.15,-1.93,;-4.57,-1.79,;-4.57,-.25,;-5.91,.52,;-5.91,2.06,;-4.57,2.83,;-3.24,2.06,;-1.77,2.53,;-1.37,4.02,;.11,4.42,;.51,5.91,;2,6.31,;3.09,5.22,;2.69,3.73,;3.78,2.64,;3.38,1.15,;5.27,3.04,;6.35,1.95,;5.66,4.53,;7.15,4.93,;4.58,5.62,;-.87,1.29,;.67,1.29,;-1.77,.04,;-1.37,-1.45,;.11,-1.84,;1.2,-.75,;2.69,-1.15,;3.09,-2.64,;2,-3.73,;.51,-3.33,;2.4,-5.22,;1.31,-6.31,;3.88,-5.62,;4.97,-4.53,;6.46,-4.93,;3.88,-3.44,;5.37,-3.04,;-3.24,.52,)|
Structure:
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