Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487573
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
 Lee, TKim, KChristov, PPBelmar, JBurke, JPOlejniczak, ETFesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487573
Synonyms:
US10954193, Example 127
Type:
Small organic molecule
Emp. Form.:
C40H41ClN4O4S
Mol. Mass.:
709.296
SMILES:
Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(Cc3cccc(c3)C(=O)NS(=O)(=O)c3ccccc3)c12 |(-3.13,-1.67,;-4.47,-2.44,;-4.94,-3.91,;-6.48,-3.91,;-7.25,-5.24,;-6.96,-2.44,;-8.29,-1.67,;-5.71,-1.54,;-5.71,0,;-7.05,.77,;-7.05,2.31,;-5.71,3.08,;-4.38,2.31,;-2.92,2.79,;-2.52,4.27,;-1.03,4.67,;-.63,6.16,;.86,6.56,;1.95,5.47,;1.55,3.98,;2.64,2.89,;2.24,1.41,;4.12,3.29,;5.21,2.2,;4.52,4.78,;6.01,5.18,;3.43,5.87,;-2.01,1.54,;-.47,1.54,;-2.92,.3,;-2.52,-1.19,;-1.03,-1.59,;.06,-.5,;1.55,-.9,;1.95,-2.39,;.86,-3.48,;-.63,-3.08,;1.25,-4.96,;.17,-6.05,;2.74,-5.36,;3.83,-4.27,;2.74,-3.19,;4.23,-2.79,;5.32,-4.67,;5.72,-6.16,;7.2,-6.56,;8.29,-5.47,;7.9,-3.98,;6.41,-3.58,;-4.38,.77,)|
Structure:
Search PDB for entries with ligand similarity: