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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487578
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
IC50
<100.0±n/a nM
Citation
 Lee, T; Kim, K; Christov, PP; Belmar, J; Burke, JP; Olejniczak, ET; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487578
Synonyms:
US10954193, Example 134
Type:
Small organic molecule
Emp. Form.:
C33H34Cl2N4O3
Mol. Mass.:
605.554
SMILES:
Cc1nn(C)c(C)c1-c1c(Cl)ccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c(C)n(Cc3ccc(cn3)C(O)=O)c12 |(-1.95,-2.33,;-3.28,-3.1,;-3.76,-4.57,;-5.3,-4.57,;-6.07,-5.9,;-5.77,-3.1,;-7.11,-2.33,;-4.53,-2.2,;-4.53,-.66,;-5.86,.11,;-7.2,-.66,;-5.86,1.65,;-4.53,2.42,;-3.19,1.65,;-1.73,2.13,;-1.33,3.62,;.16,4.01,;.55,5.5,;2.04,5.9,;3.13,4.81,;2.73,3.32,;3.82,2.24,;3.42,.75,;5.31,2.63,;6.4,1.55,;5.71,4.12,;7.2,4.52,;4.62,5.21,;-.82,.88,;.72,.88,;-1.73,-.36,;-1.33,-1.85,;.16,-2.25,;1.25,-1.16,;2.73,-1.56,;3.18,-3.06,;2.04,-4.14,;.55,-3.74,;4.67,-3.46,;5.07,-4.95,;5.76,-2.37,;-3.19,.11,)|
Structure:
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