Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM487510
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy Competition Assay
Ki
170±n/a nM
Citation
 Lee, TKim, KChristov, PPBelmar, JBurke, JPOlejniczak, ETFesik, SW Substituted indole Mcl-1 inhibitors US Patent  US10954193 Publication Date 3/23/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM487510
Synonyms:
US10954193, Example 44
Type:
Small organic molecule
Emp. Form.:
C23H25Cl2NO3
Mol. Mass.:
434.356
SMILES:
Cc1c(CCCOc2cc(C)c(Cl)c(C)c2)c2ccc(Cl)cc2n1CCC(O)=O
Structure:
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