Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Ligand
BDBM487687
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
10.00±n/a nM
Citation
 Lu, TAllison, BDBarbay, JKConnolly, PJCummings, MDDiels, GEdwards, JPKreutter, KDPhilippar, UShen, FThuring, JWWu, TBerthelot, DJ Pyrazole derivatives as MALT1 inhibitors US Patent  US10954214 Publication Date 3/23/2021 
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms:
MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase
Type:
Enzyme
Mol. Mass.:
92257.81
Organism:
Homo sapiens (Human)
Description:
Q9UDY8
Residue:
824
Sequence:
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
  
Inhibitor
Name:
BDBM487687
Synonyms:
2-(3-chloro-5-(1-(quinolin-5-yl)- 5-(trifluoromethyl)-1H-pyrazole- 4-carboxamido)pyridin-2-yl)- 2H-1,2,3-triazole-4-carboxylic acid | US10954214, Compound 109
Type:
Small organic molecule
Emp. Form.:
C22H12ClF3N8O3
Mol. Mass.:
528.831
SMILES:
OC(=O)c1cnn(n1)-c1ncc(NC(=O)c2cnn(c2C(F)(F)F)-c2cccc3ncccc23)cc1Cl
Structure:
Search PDB for entries with ligand similarity: