| Assay Method Information | |
| | Dose-response biochemical assay for inhibitors of Matrix Metalloproteinase 13 (MMP13) activity |
| Description: | Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay Provider: Florida Atlantic University Network: Molecular Library Screening Center Network (MLSCN) Proposal Number: 1 X01 MH078948-01 External Assay ID: MMP13_INH_fTHP_1536_IC50 Name: Dose-response biochemical assay for inhibitors of Matrix Metalloproteinase 13 (MMP13) activity Description: Osteoarthritis (OA) is an age-related debilitating disease affecting more than 80% of people over the age of 75, caused by the destruction of articular cartilage (1). The major components of the cartilage extracellular matrix (ECM) are type II collagen and the chondroitin sulfate proteoglycan, aggrecan (2). Proteases with potential roles in OA include MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5 (3). MMP-13 is believed to be the more prominent collagenase in OA (3,4). Initial clinical trials with MMP inhibitors targeting active site were disappointing, due |
| Affinity data for this assay | |
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