| Assay Method Information | |
| | Dose-response biochemical assay for inhibitors of Focal Adhesion Kinase (FAK) |
| Description: | Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay Provider: Scripps Florida Network: Molecular Library Screening Center Network (MLSCN) Grant Proposal Number: Not Applicable PI: Peter Hodder External Assay ID: FAK_INH_TRFRET_1536_IC50 Name: Dose-response biochemical assay for inhibitors of Focal Adhesion Kinase (FAK) Description: The focal adhesion kinase (FAK) is a tyrosine kinase involved in growth factor and integrin mediated signal transduction pathways [1]. It controls cell motility and migration by regulating the turnover of focal adhesions [2]. The expression of FAK is elevated in malignant breast cancer and its activity is required in vitro for the invasion of breast carcinoma cells and in vivo for lethal metastasis formation in mice [3]. Moreover, FAK mRNA expression has been shown to be increased in human metatstatic tumors as well as invasive tumors, compared to normal, |
| Affinity data for this assay | |
|---|---|
| If you find an error in this entry please send us an E-mail | |