| Assay Method Information | |
| | Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity |
| Description: | Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute (TSRI) Assay Provider: Steven Brown, TSRI Network: Molecular Library Screening Center Network (MLSCN) Grant Proposal Number: 1 R21 NS057101-01 Grant Proposal PI: Steven Brown External Assay ID: NFAT_INH_BLA_1536_ IC50 Name: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity Description: Galanin, a 29 amino acid neuropeptide (30 residues in humans), is cleaved from preprogalanin and is involved in many physiological processes including nervous system development, feeding, metabolism and reproduction, and regulation of neurotransmitter and hormone release [1, 2]. The physiologic response to galanin is mediated in part by three G protein-coupled metabotropic 7-transmembrane receptor subtypes, GALR1, GALR2 and GALR3. These receptors are expressed t |
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