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Assay Method Information

Assay Name:  Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation
Description:  Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Jerry Pelletier, McGill UNIVERSITY MLSCN Grant: 1 R03 MH081216-01 Title: Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation Assay Overview The recruitment of the 40S ribosomal subunit and associated factors (43S pre-initiation complex) to the mRNA during translation initiation is highly regulated by eukaryotic initiation factor (eIF) 4F. This complex consists of three subunits: (i) eIF4E, the cap-binding protein responsible for binding of the complex to the mRNA cap structure; (ii) eIF4A, an RNA helicase thought to be required to unwind 5' proximal local mRNA secondary structure to facilitate access of the 43S ribosomal complex to the mRNA template; and (iii) eIF4G, a modular scaffold that mediates mRNA binding to the
Affinity data for this assay
 

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Last update November 1, 2007
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