Assay Method Information

Assay Name:  Fluorescence-based biochemical dose response assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4)
Description:  Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: Paul Thompson, University of South Carolina Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: R01 GM079357-01 Grant Proposal PI: Paul Thompson External Assay ID: PAD4_INH_FLUO_2X%IC50 Name: Fluorescence-based biochemical dose response assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4). Description: Rheumatoid Arthritis (RA) is a chronic and progressive autoimmune disorder that affects about one percent of the US population (1). Existing therapies treat the symptoms of the disease but not the underlying cause, and are associated with numerous side effects (2). The activity of Protein Arginine Deiminase 4 (PAD4), one of four known active PAD isozymes, is increased in RA; where it is thought to generate a subset of antigens that the immune system recognizes as foreign (
Affinity data for this assay
 

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