| Assay Method Information | |
| | Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1) |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: Patricia McDonald, TSRI Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: R01 DA023915-02 Grant Proposal PI: Patricia McDonald External Assay ID: OX1R_ANT_FLUO8_1536_3XIC50 DRUN Name: Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1). Description: Heterotrimeric G-protein coupled receptors (GPCRs) are major targets for disease therapeutics, due in part to their broad tissue distribution, structural diversity, varied modes of action, and disease association (1-4). Most non-sensory GPCRs are expressed in the brain and regulate critical neuronal functions involved in feeding, sleep, mood, and addiction (5, 6). For example, in the lateral hypothalamic region of the brain, two orexin neuropeptides (orexin A and orexin |
| Affinity data for this assay | |
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