| Assay Method Information | |
| | Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Cdr1 with Hit compounds from Cherry Pick1 |
| Description: | UNMCMD Assay Overview: Assay Support: 1 R03 MH087406-01A1 Project Title: Identification of broad-spectrum antifungal efflux pump inhibitors PI: Richard Cannon Screening Center PI: Larry Sklar / UNMCMD Chemistry Center PI: Craig Lindsley Assay Implementation: J Jacob Strouse, Susan Young, Stephanie Sedillo, Domanique Perez, Matthew Garcia, Travis Houston, Keon Ahghar, Terry Foutz, Anna Waller, Annette Evangelisti, Mark Carter, Virginia Salas Assay Background and Significance: Fungal infections, exemplified by oral and invasive candidiasis, cause considerable morbidity and mortality in the immunocompromised. Treatment of patients with fungal infections is severely hampered by the development of antifungal drug resistance [Cannon, et al 2009]. The goal of this project is to address this health need by discovering novel chemical compounds that reverse antifungal drug resistance by inhibiting the drug efflux pump molecules in the fungal cell membrane, overexpression of |
| Affinity data for this assay | |
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