| Assay Method Information | |
| | TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: Corinne Lasmezas, The Scripps Research Institute Molecular Screening Center Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: 1 R03 DA035192-01 Grant Proposal PI: Corinne Lasmezas, The Scripps Research Institute Molecular Screening Center External Assay ID: PRPC_INH_TRFRET_1536_3XIC50 DRUN Name: TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) Description: Prion diseases are lethal infectious neurodegenerative diseases affecting animals and humans [1]. In humans, Creutzfeldt-Jakob Disease (CJD) is either sporadic, affecting mainly people over 60 years, iatrogenic, or genetic with a high penetrance. Prion diseases are characterized by the accumulation, in brain and lymphoid tissue of PrPsc [2], a misfolded, aggrega |
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