Assay Method Information

Assay Name:  Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer
Description:  Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: Harvard Medical School/Massachusetts General Hospital Assay Provider: Peter Caravan, Harvard Medical School/Massachusetts General Hospital Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: R21 NS075627 Grant Proposal PI: Peter Caravan, Harvard Medical School/Massachusetts General Hospital External Assay ID: FIBRIN-TN7_INH_FP_1536_3XIC50 DRUN Name: Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )]. Description: Fibrin is an insoluble biopolymer that is formed by the proteolytic action of thrombin on the clotting factor fibrinogen. It constitutes the major protein component of blood clots and is generally associated with pathologies such as ischemic stro
Affinity data for this assay
 

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