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Assay Method Information

Assay Name:  Inhibition of SARS-CoV-2 PLpro by SARS-CoV PLpro Inhibitors
Description:  Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 50 μM.3 The most potent of these four proved to be GRL-0617 with an IC50 of 2.4 μM, followed by compound 6 with a low micromolar IC50 of 5.0 μM toward SARS-CoV-2.
Affinity data for this assay
 

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Last update November 1, 2007
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