Assay Method Information

Assay Name:  Mtb cytochrome bd inhibition assay
Description:  The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmacological effects of the cytochrome bd inhibitors of the present invention.Although the pharmacological properties of the cytochrome bd inhibitors described herein vary with structural change, as expected, the cytochrome bd inhibitors of the invention were found to be active in these assays.The cytochrome bd inhibitors of the invention demonstrate a IC50 of 20 μM or less in the Mtb cytochrome bd inhibition assay described herein, with preferred cytochrome bd inhibitors of the invention demonstrating an IC50 of 5 μM or less and the most preferred cytochrome bd inhibitors of the invention demonstrating an IC50 of 1 μM or less.
Affinity data for this assay
 

If you find an error in this entry please send us an E-mail