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42 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.EBI
Pfizer
Recent advances in the development of acetyl-CoA carboxylase (ACC) inhibitors for the treatment of metabolic disease.EBI
Amgen
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.EBI
Pfizer
Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase.EBI
Amgen
Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure.EBI
Pfizer
Treatment of Obesity and Related Disorders with Acetyl-CoA Carboxylase Inhibitors.EBI
Therachem Research Medilab (India)
The lipogenesis pathway as a cancer target.EBI
Wayne State University
Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors.EBI
Takeda Pharmaceutical
Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors.EBI
Takeda Pharmaceutical
Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.EBI
Taisho Pharmaceutical
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.EBI
Abbott Laboratories
Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase.EBI
Pfizer
Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.EBI
Takeda Pharmaceutical
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.EBI
Astrazeneca Research And Development
Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation.EBI
Sanofi-Aventis Deutschland
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.EBI
Pfizer
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.EBI
Taisho Pharmaceutical
Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.EBI
Bristol-Myers Squibb Research And Development
Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors.EBI
Torrent Pharmaceuticals
2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors.EBI
Bristol-Myers Squibb Pharmaceutical Research Institute
N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications.EBI
Abbott Laboratories
Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents.EBI
Abbott Laboratories
The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications.EBI
Abbott Laboratories
Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.EBI
Abbott Laboratories
Novel Thienopyrimidines as Acetyl-CoA Carboxylase Inhibitors for Treating Liver Diseases.EBI
Smith, Gambrell & Russell
Cyclohexanedione herbicides are inhibitors of rat heart acetyl-CoA carboxylase.EBI
Eli Lilly
Synthesis and in vitro evaluation of novel spiroketopyrazoles as acetyl-CoA carboxylase inhibitors and potential antitumor agents.EBI
Xuzhou Medical University
Design and synthesis of a monocyclic derivative as a selective ACC1 inhibitor by chemical modification of biphenyl ACC1/2 dual inhibitors.EBI
Takeda Pharmaceutical
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.EBI
Pfizer
The identification and pharmacological evaluation of potent, selective and orally available ACC1 inhibitor.EBI
Takeda Pharmaceutical
The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.EBI
Terns Pharmaceuticals
Design and synthesis of a novel 1H-pyrrolo[3,2-b]pyridine-3-carboxamide derivative as an orally available ACC1 inhibitor.EBI
Takeda Pharmaceutical
Design, synthesis and biological evaluation of novel spiro-pentacylamides as acetyl-CoA carboxylase inhibitors.EBI
China Pharmaceutical University
Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy.EBI
Shionogi
Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors.EBI
Takeda Pharmaceutical