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388 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold.EBI
Shanghai Institute Of Materia Medica
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity.EBI
Universit£
Importance of 5/6-aryl substitution on the pharmacological profile of 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid derived PPAR¿ agonists.EBI
University Of Innsbruck
Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of novel quinoxaline derivatives as potential PPAR¿ and SUR agonists.EBI
Al-Azhar University
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CHEBI
Jagiellonian University Medical College
Evaluation of selected 3D virtual screening tools for the prospective identification of peroxisome proliferator-activated receptor (PPAR)¿ partial agonists.EBI
University Of Innsbruck
New telmisartan-derived PPAR¿ agonists: Impact of the 3D-binding mode on the pharmacological profile.EBI
Universit£T Innsbruck
Discovery of phenoxyindazoles and phenylthioindazoles as ROR¿ inverse agonists.EBI
Galderma R & D
Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptora/d (PPARa/d) dual agonistic activity.EBI
The University Of Tokyo
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist.EBI
Bristol-Myers Squibb
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.EBI
Jagiellonian University Medical College
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor.EBI
Central Pharmaceutical Research Institute
Synthetic approaches to the 2014 new drugs.EBI
Pfizer
Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria.EBI
Max Planck Institute For Molecular Genetics
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor¿ Modulators.EBI
Goethe-University Frankfurt
Design and synthesis of novel Y-shaped barbituric acid derivatives as PPAR¿ activators.EBI
National Institute Of Pharmaceutical Education And Research (Niper)
Characterization of isobutylhydroxyamides with NGF-potentiating activity from Zanthoxylum bungeanum.EBI
Northwest A & F University
Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.EBI
Pfizer
Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological Evaluation.EBI
Iqm-Csic
Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.EBI
Genentech
Design, synthesis, and biological evaluation of a series of alkoxy-3-indolylacetic acids as peroxisome proliferator-activated receptor¿/d agonists.EBI
Sookmyung Women'S University
Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands.EBI
Goethe-University Frankfurt
2-(2-Bromophenyl)-formononetin and 2-heptyl-formononetin are PPAR¿ partial agonists and reduce lipid accumulation in 3T3-L1 adipocytes.EBI
University Of Copenhagen
Amorfrutins Are Natural PPAR¿ Agonists with Potent Anti-inflammatory Properties.EBI
Max Planck Institute For Molecular Genetics
Thiazolidine-2,4-dione derivatives: programmed chemical weapons for key protein targets of various pathological conditions.EBI
Punjabi University
Peroxisome Proliferator-Activated Receptor¿ (PPAR¿) and Ligand Choreography: Newcomers Take the Stage.EBI
Universitat Rovira I Virgili (Urv)
Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist.EBI
Daiichi Sankyo
Separation and peroxisome proliferator-activated receptor-¿ agonist activity evaluation of synthetic racemic bavachinin enantiomers.EBI
Shanghai University Of Traditional Chinese Medicine
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARa/¿ agonists.EBI
Bristol-Myers Squibb Research And Development (R & D)
SAR-studies of¿-secretase modulators with PPAR¿-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.EBI
Goethe-University Frankfurt
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptora/¿ ligand LT175.EBI
Universit£
Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARa/¿ activation and dual 5-LO/mPGES-1 inhibition.EBI
Goethe-University Frankfurt
Molecular determinants for improved activity at PPARa: structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARa.EBI
Goethe-University Frankfurt
Molecular dynamics study-guided identification of cyclic amine structures as novel hydrophobic tail components of hPPAR¿ agonists.EBI
Okayama University
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).EBI
Glaxosmithkline
Biological evaluation and structural insights for design of subtype-selective peroxisome proliferator activated receptor-a (PPAR-a) agonists.EBI
National Institute Of Pharmaceutical Education And Research (Niper)
Structural development studies of PPARs ligands based on tyrosine scaffold.EBI
Universit£&Quot;G. D'Annunzio&Quot
Polyyne hybrid compounds from Notopterygium incisum with peroxisome proliferator-activated receptor gamma agonistic effects.EBI
Karl-Franzens-University Graz
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t.EBI
Phenex Pharmaceuticals
Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist.EBI
Goethe-University Frankfurt
The dipeptide H-Trp-Glu-OH (WE) shows agonistic activity to peroxisome proliferator-activated protein-a and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells.EBI
Korea University
Identification of the first potent, selective and bioavailable PPARa antagonist.EBI
Inception Sciences
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.EBI
Glaxo Wellcome Research And Development
Discovery of INT131: a selective PPAR¿ modulator that enhances insulin sensitivity.EBI
Amgen
Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor¿.EBI
Helmholtz Centre For Infection Research
The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.EBI
The University Of Sydney
Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿.EBI
Pfizer
Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.EBI
Pfizer
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptora/¿ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.EBI
Universit�
Co-crystal structure guided array synthesis of PPARgamma inverse agonists.EBI
Glaxosmithkline
QSAR analysis of PPAR-gamma agonists as anti-diabetic agents.EBI
Central Drug Research Institute
Phenoxyacetic acids as PPARd partial agonists: synthesis, optimization, and in vivo efficacy.EBI
Glaxosmithkline
Flexible ligand recognition of peroxisome proliferator-activated receptor-gamma (PPARgamma).EBI
Rikkyo University
Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.EBI
Glaxosmithkline
PPAR¿ agonist from Chromolaena odorata.EBI
Hebei Medical University
Synthesis and structure-activity relationships of fibrate-based analogues inside PPARs.EBI
Universit£
Design, synthesis and evaluation of novel zwitterionic compounds as PPARa/¿ dual agonists (1).EBI
Daiichi Sankyo
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.EBI
Istituto Tumori&Quot;Giovanni Paolo Ii&Quot
Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors.EBI
Zafes/Liff/Osf Goethe-University Frankfurt
Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor¿.EBI
Universit£
Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists.EBI
National Kaohsiung Normal University
Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-¿B activation and PPAR transcriptional activity.EBI
Chungnam National University
Design, synthesis and in vitro evaluation of a series ofa-substituted phenylpropanoic acid PPAR¿ agonists to further investigate the stereochemistry-activity relationship.EBI
Okayama University
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.EBI
University Of Innsbruck
Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors.EBI
Institut Pasteur Korea
Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.EBI
Universit£
Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds.EBI
Trinity College
Synthesis and biological evaluation of novel (-)-Cercosporamide derivatives as potent selective PPAR¿ modulators.EBI
Daiichi Sankyo
Activity landscape modeling of PPAR ligands with dual-activity difference maps.EBI
Universidad Nacional Aut£Noma De M£Xico
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptord agonists as potent anti-obesity agents in vivo.EBI
Seoul National University
Polyhydroxylated macrolides from Seimatosporium discosioides and their effects on the activation of peroxisome proliferator-activated receptor gamma.EBI
Korea University
Total synthesis and dual PPARa/¿ agonist effects of amorphastilbol and its synthetic derivatives.EBI
Korea Institute Of Science And Technology
Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR)¿ Agonists.EBI
Takeda Pharmaceutical
Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.EBI
Chungnam National University
Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents.EBI
Johnson & Johnson Pharmaceutical Research And Development
Design, synthesis, and structural analysis of phenylpropanoic acid-type PPAR¿-selective agonists: discovery of reversed stereochemistry-activity relationship.EBI
Okayama University
Design, synthesis, and structure-activity relationship studies of novel 2,4,6-trisubstituted-5-pyrimidinecarboxylic acids as peroxisome proliferator-activated receptor gamma (PPARgamma) partial agonists with comparable antidiabetic efficacy to rosiglitazone.EBI
Kyorin Pharmaceutical
(S)-3-(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-(piperazin-1-yl) propanoic acid compounds: synthesis and biological evaluation of dual PPARalpha/gamma agonists.EBI
Institute Of Pharmacology And Toxicology
Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives.EBI
Daiichi Sankyo
Identification of (beta-carboxyethyl)-rhodanine derivatives exhibiting peroxisome proliferator-activated receptor gamma activity.EBI
Sookmyung Women'S University
Acidic elements in histamine H(3) receptor antagonists.EBI
Johann Wolfgang Goethe University
Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes.EBI
Chinese Academy Of Sciences
Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling.EBI
Graduate School Of The Chinese Academy Of Sciences
Modulation of PPAR receptor subtype selectivity of the ligands: aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety.EBI
Zydus Research Centre
Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.EBI
Seoul National University
Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.EBI
Bristol-Myers Squibb R & D
Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARalpha.EBI
Usda-Ars
Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling.EBI
Bristol-Myers Squibb
Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists.EBI
Johnson & Johnson Pharmaceutical Research And Development
Structure-activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.EBI
Nippon Shinyaku
SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail.EBI
University Of Tokyo
Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.EBI
Nippon Shinyaku
Omega-(2-Naphthyloxy) amino alkanes as a novel class of anti-hyperglycemic and lipid lowering agents.EBI
Central Drug Research Institute
Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.EBI
Bristol-Myers Squibb Research And Development
Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.EBI
Johnson & Johnson
Design of a partial PPARdelta agonist.EBI
Novo Nordisk
Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARgamma ligands (I).EBI
Fudan University
Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents.EBI
Eli Lilly
Design and synthesis of the first generation of dithiolane thiazolidinedione- and phenylacetic acid-based PPARgamma agonists.EBI
University Of Mississippi
Designed multiple ligands. An emerging drug discovery paradigm.EBI
Organon Laboratories
O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.EBI
Merck Research Laboratories
Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: synthesis and structure-activity relationship.EBI
Sankyo
Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes.EBI
Korea University
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptorsa/¿ dual agonists.EBI
Universit£
Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPAR¿ partial agonists.EBI
Daiichi Sankyo
Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor¿ (PPAR¿) modulators.EBI
Merck Research Laboratories
A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR)¿ agonists: design and synthesis of benzylpyrazole acylsulfonamides.EBI
Takeda Pharmaceutical
Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor¿ selective agonists with protein-tyrosine phosphatase 1B inhibition.EBI
Kyoto Pharmaceutical Industries
Discovery of cyclic amine-substituted benzoic acids as PPARa agonists.EBI
Kyorin Pharmaceutical
Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516.EBI
University Of Oslo
SAR studies of acidic dual¿-secretase/PPAR¿ modulators.EBI
Goethe-University Frankfurt
Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists: relationship between absolute configuration and subtype selectivity.EBI
The University Of Tokyo
Revisiting glitazars: thiophene substituted oxazole containinga-ethoxy phenylpropanoic acid derivatives as highly potent PPARa/¿ dual agonists devoid of adverse effects in rodents.EBI
Zydus Research Centre
Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-¿ activators.EBI
Inha University
Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿.EBI
Pfizer
Discovery of new nanomolar peroxisome proliferator-activated receptor κ activators via elaborate ligand-based modeling.EBI
Universiti Sains Malaysia
Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives.EBI
Guiyang Medical College
Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR)a-selective agonists.EBI
Okayama University
Biological evaluation of novel benzisoxazole derivatives as PPARd agonists.EBI
Nippon Chemiphar
Synthesis and pharmacological evaluation of novel benzoylazole-based PPARa/κ activators.EBI
Dainippon Sumitomo Pharma
Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARd agonists.EBI
Astrazeneca R&D Charnwood
Development of a new class of benzoylpyrrole-based PPARa/¿ activators.EBI
Dainippon Sumitomo Pharma
Synthesis of a novel human PPARd selective agonist and its stimulatory effect on oligodendrocyte differentiation.EBI
Nippon Chemiphar
Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.EBI
Zydus Research Centre
Selective peroxisome proliferator-activated receptord isosteric selenium agonists as potent anti-atherogenic agents in vivo.EBI
Seoul National University
1,3-Diphenyl-1H-pyrazole derivatives as a new series of potent PPAR¿ partial agonists.EBI
Sookmyung Women'S University
Characterization of new PPARgamma agonists: benzimidazole derivatives-importance of positions 5 and 6, and computational studies on the binding mode.EBI
Freie UniversitäT Berlin
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.EBI
Phenex Pharmaceuticals
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.EBI
Zafes/Liff/Goethe University Frankfurt
Synthesis and anti-inflammatory activity of new arylidene-thiazolidine-2,4-diones as PPARgamma ligands.EBI
Universidade Federal De Pernambuco
Glycine amides as PPARalpha agonists.EBI
Bayer-Schering Pharma
Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.EBI
Bristol-Myers Squibb R & D
Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators.EBI
Goethe-University Frankfurt
Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator.EBI
Goethe-University Frankfurt
Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).EBI
Bristol-Myers Squibb
Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.EBI
The Genomics Institute Of The Novartis Research Foundation
Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta selective antagonists.EBI
The University Of Tokyo
Design and synthesis of novel bis-oximinoalkanoic acids as potent PPARalpha agonists.EBI
Zydus Research Centre
Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators.EBI
Glaxosmithkline
7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.EBI
The University Of Sydney
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.EBI
Universit£
Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists.EBI
Goethe-University Frankfurt
Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation.EBI
Wake Forest University
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.EBI
Umr Gicc
Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia.EBI
Merck Research Laboratories
 
Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligandsEBI
TBA
 
Non thiazolidinedione antihyperglycaemic agents. 2: α-Carbon substituted β-phenylpropanoic acids1EBI
TBA
 
Non thiazolidinedione antihyperglycaemic agents. 1: α-Heteroatom substituted β-phenylpropanoic acidsEBI
TBA
Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma aEBI
Merck Research Laboratories
Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.EBI
F. Hoffmann-La Roche
Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.EBI
National Health Research Institutes
Selective, potent PPARgamma agonists with cyclopentenone core structure.EBI
Universidade De Vigo
Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.EBI
Bristol-Myers Squibb Research And Development
The discovery of equipotent PPARalpha/gamma dual activators.EBI
Glaxosmithkline
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.EBI
Università
Discovery of novel PPAR ligands by a virtual screening approach based on pharmacophore modeling, 3D shape, and electrostatic similarity screening.EBI
University Of Innsbruck
Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma.EBI
National Health Research Institutes
Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.EBI
Zydus Research Centre
Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARalpha/gamma dual agonists.EBI
Yuhan Research Institute
Highly functionalized 7-azaindoles as selective PPAR gamma modulators.EBI
Merck Research Laboratories
Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition.EBI
Vanderbilt University Center For Structural Biology
Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part.EBI
The University Of Tokyo
Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.EBI
Zydus Research Centre
Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells.EBI
Kyoto Pharmaceutical University
Synthesis and evaluation of a series of benzopyran derivatives as PPAR alpha/gamma agonists.EBI
Graduate School Of The Chinese Academy Of Sciences
CoMFA analysis of dual/multiple PPAR activators.EBI
National Institute Of Pharmaceutical Education And Research
Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells.EBI
University Of Mississippi
Two new furanoditerpenes from Saururus chinenesis and their effects on the activation of peroxisome proliferator-activated receptor gamma.EBI
Korea Research Institute Of Bioscience And Biotechnology
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part I: synthesis and pharmacological evaluation.EBI
Spot-Ea3857
Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists.EBI
Glaxosmithkline
Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activation.EBI
Boehringer Ingelheim Pharma
Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists.EBI
Eli Lilly
Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.EBI
Wyeth Pharmaceuticals
Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists.EBI
Korea Research Institute Of Chemical Technology
Mycophenolic acid as a latent agonist of PPARgamma.EBI
Hokkaido University
Indanylacetic acids as PPAR-delta activator insulin sensitizers.EBI
Bayer Research Center
Design and synthesis of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid derivatives as PPARgamma activators.EBI
National Institute Of Pharmaceutical Education And Research
Novel selective PPARdelta agonists: optimization of activity by modification of alkynylallylic moiety.EBI
Re&D Vufb
Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor alpha agonists.EBI
Kowa
Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.EBI
University Of Tokyo
Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.EBI
Nagoya City University
Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists.EBI
Johnson And Johnson Pharmaceutical Research And Development
Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.EBI
Pfizer
Design, synthesis, and structure-activity relationship of carbamate-tethered aryl propanoic acids as novel PPARalpha/gamma dual agonists.EBI
Seoul National University
Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) delta agonists.EBI
Pfizer
Design of potent PPARalpha agonists.EBI
Novo Nordisk
Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.EBI
Novo Nordisk
Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.EBI
Bristol-Myers Squibb Pharmaceutical Research Institute
Design and synthesis of a novel class of dual PPARgamma/delta agonists.EBI
Eli Lilly
Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists.EBI
National Health Research Institutes
Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands.EBI
Eli Lilly
Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.EBI
Pfizer
Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.EBI
Pfizer
Design and synthesis of dual peroxisome proliferator-activated receptors gamma and delta agonists as novel euglycemic agents with a reduced weight gain profile.EBI
Eli Lilly
Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.EBI
Procter And Gamble Pharmaceuticals
Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists.EBI
Korea Research Institute Of Chemical Technology
Studies towards the conception of new selective PPARbeta/delta ligands.EBI
Université
3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists: Part 1.EBI
The Genomics Institute Of The Novartis Research Foundation
Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists.EBI
F. Hoffmann-La Roche
Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.EBI
National Health Research Institutes
1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists.EBI
The Genomics Institute Of The Novartis Research Foundation
SAR studies: designing potent and selective LXR agonists.EBI
Merck Research Laboratories
Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies.EBI
National Health Research Institutes
Design and synthesis of potent and subtype-selective PPARalpha agonists.EBI
Merck Research Laboratories
Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.EBI
National Health Research Institutes
Substituted indanylacetic acids as PPAR-alpha-gamma activators.EBI
Bayer Research Center
Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor alpha/delta dual agonists.EBI
University Of Tokyo
Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARgamma partial agonists.EBI
Merck Research Laboratories
Synthesis of new carbo- and heterocyclic analogues of 8-HETE and evaluation of their activity towards the PPARs.EBI
Cnrs Umr 6052
Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity.EBI
Merck Research Laboratories
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.EBI
Università
Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.EBI
Merck Research Laboratories
(2R)-2-methylchromane-2-carboxylic acids: discovery of selective PPARalpha agonists as hypolipidemic agents.EBI
Merck Research Laboratories
Selective PPARgamma modulators with improved pharmacological profiles.EBI
Merck Research Laboratories
Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia.EBI
Merck Research Laboratories
Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.EBI
Bristol-Myers Squibb Pharmaceutical Research Institute
Benzoyl 2-methyl indoles as selective PPARgamma modulators.EBI
Merck Research Laboratories
2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents.EBI
Eli Lilly
Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes.EBI
Glaxosmithkline
Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators.EBI
Research Institute Of Tsinghua University
(2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents.EBI
Merck Research Laboratories
Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.EBI
Eli Lilly
Discovery of the first-in-class dual PPAR?/? partial agonist for the treatment of metabolic syndrome.EBI
Guangdong Pharmaceutical University
Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPAR? with potential anti-diabetic efficacy.EBI
Xiamen University
Benzoxazinones as PPARgamma agonists. 2. SAR of the amide substituent and in vivo results in a type 2 diabetes model.EBI
Johnson And Johnson Pharmaceutical Research And Development
Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.EBI
Bristol-Myers Squibb
Virtual screening and biological evaluation of PPAR? antagonists as potential anti-prostate cancer agents.EBI
University Of Nebraska Medical Center
Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.EBI
Eli Lilly
Design and synthesis of novel RXR-selective modulators with improved pharmacological profile.EBI
Ligand Pharmaceuticals
Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo.EBI
Novo Nordisk
Aryloxazolidinediones: identification of potent orally active PPAR dual alpha/gamma agonists.EBI
Merck Research Laboratories
Discovery of novel modulators for the PPAR? (peroxisome proliferator activated receptor ?): Potential therapies for nonalcoholic fatty liver disease.EBI
City Of Hope National Medical Center
Design and synthesis of fluorinated RXR modulators.EBI
Eli Lilly
Design, synthesis, and biological evaluation of a novel dual peroxisome proliferator-activated receptor alpha/delta agonist for the treatment of diabetic kidney disease through anti-inflammatory mechanisms.EBI
China Pharmaceutical University
Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor alpha subtype-selective activators.EBI
Kyorin Pharmaceutical
5-aryl thiazolidine-2,4-diones: discovery of PPAR dual alpha/gamma agonists as antidiabetic agents.EBI
Merck Research Laboratories
Structure-Activity Relationship Study and Biological Evaluation of 2-(Disubstituted phenyl)-indole-5-propanoic Acid Derivatives as GPR40 Full Agonists.EBI
Sungkyunkwan University
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes.EBI
Ligand Pharmaceuticals
Identification and development of non-cytotoxic cell death modulators: Impact of sartans and derivatives on PPAR? activation and on growth of imatinib-resistant chronic myelogenous leukemia cells.EBI
University Of Innsbruck
The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470).EBI
Lilly Research Laboratories
5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists.EBI
Merck Research Laboratories
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.EBI
Glaxosmithkline
Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar.EBI
Novo Nordisk
Phenylacetic acid derivatives as hPPAR agonists.EBI
Merck Research Laboratories
Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists.EBI
Merck Research Laboratories
Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.EBI
Novo Nordisk
Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators.EBI
Biovitrum
Selective PPAR? Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD).EBI
Mitobridge
Synthesis and biological evaluations of marine oxohexadecenoic acids: PPAR?/? dual agonism and anti-diabetic target gene effects.EBI
University Of Oslo
Discovery of a Novel Class of ERR? Agonists.EBI
Daiichi Sankyo
Tetrazanbigen Derivatives as Peroxisome Proliferator-Activated Receptor Gamma (PPAR?) Partial Agonists:?Design, Synthesis, Structure-Activity Relationship, and Anticancer Activities.EBI
Chongqing Medical University
Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPAR?/? Modulators.EBI
Seoul National University
A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor ? Binding Properties and Biological Activities.EBI
Aix Marseille University
Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities.EBI
Albany College Of Pharmacy And Health Sciences
Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities.EBI
Takeda Chemical Industries
Discovery of 3?,7?,11?-Trihydroxy-6?-ethyl-5?-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders.EBI
Tes Pharma
Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.EBI
Novo Nordisk
Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor alpha.EBI
Kyorin Pharmaceutical
Kojyl cinnamate esters are peroxisome proliferator-activated receptor ?/? dual agonists.EBI
Seoul National University
Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARalpha-selective activators.EBI
Kyorin Pharmaceutical
Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight.EBI
Glaxosmithkline
Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor ? (PPAR?).EBI
New York University
Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis.EBI
Glaxosmithkline
2-Phenyl-8-(1-phenylallyl)-chromenone compounds have a pan-PPAR modulator pharmacophore.EBI
Seoul National University
Structure-Activity Relationship Studies of 3- or 4-Pyridine Derivatives of DS-6930.EBI
Daiichi Sankyo
Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta.EBI
Glaxosmithkline
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPAR?.EBI
Goethe-University Frankfurt
Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.EBI
Eli Lilly
Anti-diabetic drugs recent approaches and advancements.EBI
Mizoram University
Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis.EBI
Glaxosmithkline
The Oxidation of Phytocannabinoids to Cannabinoquinoids.EBI
Universit£
Sulfonimide and Amide Derivatives as Novel PPAR? Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies.EBI
"G. D'Annunzio" University Of Chieti-Pescara
Polyacetylenes from EBI
University Of Vienna
Addressing hERG activity while maintaining favorable potency, selectivity and pharmacokinetic properties of PPAR? modulators.EBI
Mitobridge
Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor ?.EBI
Seoul National University
Discovery of Second Generation ROR? Inhibitors Composed of an Azole Scaffold.EBI
Kyoto Prefectural University Of Medicine
Non-canonical modulators of nuclear receptors.EBI
Vitae Pharmaceuticals
Discovery of BR102375, a new class of non-TZD PPAR? full agonist for the treatment of type 2 diabetes.EBI
Boryung Pharmaceuticals
Novel Phenyldiazenyl Fibrate Analogues as PPAR ?/?/? Pan-Agonists for the Amelioration of Metabolic Syndrome.EBI
University Of Chieti "G. D.Annunzio
Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor ?/? (PPAR?/?) dual agonists.EBI
The University Of Tokyo
Discovery of first-in-class thiazole-based dual FFA1/PPAR? agonists as potential anti-diabetic agents.EBI
Guangdong Pharmaceutical University
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.EBI
Goethe University Frankfurt
Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPAR? Drug Pioglitazone.EBI
The Scripps Research Institute
The PPARs: from orphan receptors to drug discovery.EBI
Glaxo Wellcome Research & Development
Novel berberine-based derivatives with potent hypoglycemic activity.EBI
Guizhou Medical University
Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.EBI
Glaxo Wellcome Research And Development
Role of sulphur-heterocycles in medicinal chemistry: An update.EBI
Maharaja Ranjit Singh Punjab Technical University
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.EBI
Genomics Institute Of The Novartis Research Foundation (Gnf)
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.EBI
Glaxo Wellcome Research & Development
Novel thiazolidines: Synthesis, antiproliferative properties and 2D-QSAR studies.EBI
University Of Texas-Arlington
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands.EBI
Universit£
Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPAR?-selective agonist.EBI
University Of Oslo
Structure-activity relationship and synthetic methodologies of ?-santonin derivatives with diverse bioactivities: A mini-review.EBI
Shanghai Ocean University
Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPAR?)-selective agonists.EBI
Okayama University
(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents.EBI
Kyorin Pharmaceutical
Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor ?t (ROR?t) Inverse Agonists.EBI
Technische Universiteit Eindhoven
Differential activity of rosiglitazone enantiomers at PPAR gamma.EBI
Glaxo Wellcome Research And Development
Overcoming imatinib resistance in chronic myelogenous leukemia cells using non-cytotoxic cell death modulators.EBI
University Of Innsbruck
Structure optimization of a new class of PPAR? antagonists.EBI
Fraunhofer Institute For Molecular Biology And Applied Ecology Ime
Design, synthesis, and evaluation of potent novel peroxisome proliferator-activated receptor ? indole partial agonists.EBI
The University Of Oklahoma Health Science Center
A Selective Modulator of Peroxisome Proliferator-Activated Receptor ? with an Unprecedented Binding Mode.EBI
Goethe-University Frankfurt
Multitarget PPAR? agonists as innovative modulators of the metabolic syndrome.EBI
University Of Chieti "G. D.Annunzio
Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPAR? Agonists as Leads for Retinal Disorders.EBI
University Of Oklahoma
The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.EBI
Terns Pharmaceuticals
Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPAR?/PPAR? Agonist Activity and Anti-inflammatory Effect.EBI
University Of Valencia
Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as ROR??t Allosteric Inhibitors for Autoimmune DiseasesEBI
Merck
Adiponectin-Secretion-Promoting Phenylethylchromones from the Agarwood of Aquilaria malaccensis.EBI
Seoul National University
Discovery of potent and selective PPAR?/? dual antagonists and initial biological studies.EBI
Inception Sciences
Identification of BR101549 as a lead candidate of non-TZD PPAR? agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR.EBI
Boryung Pharmaceuticals
Structure-Based and Property-Driven Optimization of EBI
Global Discovery Chemistry
Mechanistic Insight on the Mode of Action of Colletoic Acid.EBI
The University Of Tennessee Health Science Center
Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold.EBI
Hokkaido University
Discovery of a Novel Selective Dual Peroxisome Proliferator-Activated Receptor ?/? Agonist for the Treatment of Primary Biliary Cirrhosis.EBI
Wuxi Apptec (Shanghai) Co.
Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo.EBI
Ume£
Identification of dual PPAR?/? agonists and their effects on lipid metabolism.EBI
The University Of Sydney
Antiviral activity of benzotriazole derivatives. 5-[4-(Benzotriazol-2-yl)phenoxy]-2,2-dimethylpentanoic acids potently and selectively inhibit Coxsackie Virus B5.EBI
Universit£
Design, Synthesis, and Biological Evaluation of Indole Biphenylcarboxylic Acids as PPAR? Antagonists.EBI
The Scripps Research Institute
Sterol fatty acid esters from the mushroom Hericium erinaceum and their PPAR transactivational effects.EBI
Yeungnam University
Diphenylpropane Derivatives as Agonist of PPAR Nuclear Receptors.EBI
Dart Neuroscience
Structure-based identification of novel PPAR gamma ligands.EBI
Universidade Federal Do Abc
Adipogenetic effects of retrofractamide A derivatives in 3T3-L1 cells.EBI
Kyoto Pharmaceutical University
Discovery of new PPAR? agonists based on arylopeptoids.EBI
University Of Copenhagen
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors ?/? agonists.EBI
Universit£
Design and synthesis of a series of ?-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility.EBI
Okayama University
Synthesis and antidiabetic performance of ?-amino ketone containing nabumetone moiety.EBI
Southwest University
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent.EBI
Glaxo Wellcome Research And Development
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety.EBI
Glaxo Wellcome Research And Development
Development of Dihydrodibenzooxepine Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Ligands of a Novel Binding Mode as Anticancer Agents: Effective Mimicry of Chiral Structures by Olefinic E/ Z-Isomers.EBI
Fuji Research Park, R&D Division
Stereoselective Synthesis of the Isomers of Notoincisol A: Assigment of the Absolute Configuration of this Natural Product and Biological Evaluation.EBI
Vienna University Of Technology
Design, synthesis, and biological evaluation of novel pan agonists of FFA1, PPAR? and PPAR?.EBI
Guangdong Pharmaceutical University
Discovery of the bifunctional modulator of angiotensin II type 1 receptor (AT1R) and PPAR? derived from the AT1R antagonist, Fimasartan.EBI
Boryung Pharmaceuticals
PPAR?-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development.EBI
Sptanis Pharmachem Consulting
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.EBI
Goethe University Frankfurt
Identification of the First PPAR?/? Dual Agonist Able To Bind to Canonical and Alternative Sites of PPAR? and To Inhibit Its Cdk5-Mediated Phosphorylation.EBI
Universit£
Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor ? agonist.EBI
Daegu-Gyeongbuk Medical Innovation Foundation
Design, synthesis, and evaluation of novel l-phenylglycine derivatives as potential PPAR? lead compounds.EBI
Southwest University
Structure-guided evolution of a 2-phenyl-4-carboxyquinoline chemotype into PPAR? selective agonists: New leads for oculovascular conditions.EBI
University Of Oklahoma
Sulfoximines as potent ROR? inverse agonists.EBI
Nestle Skin Health
A novel structural class of coumarin-chalcone fibrates as PPAR?/? agonists with potent antioxidant activities: Design, synthesis, biological evaluation and molecular docking studies.EBI
Shenyang Pharmaceutical University
2-Formyl-komarovicine promotes adiponectin production in human mesenchymal stem cells through PPAR? partial agonism.EBI
Seoul National University
Novel highly selective peroxisome proliferator-activated receptor ? (PPAR?) modulators with pharmacokinetic properties suitable for once-daily oral dosing.EBI
Mitobridge
Discovery of DS-6930, a potent selective PPAR? modulator. Part I: Lead identification.EBI
Daiichi Sankyo
Discovery of DS-6930, a potent selective PPAR? modulator. Part II: Lead optimization.EBI
Daiichi Sankyo
SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.EBI
Sungkyunkwan University
Anti-diabetic activity of fused PPAR?-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.EBI
University Of Lille
Indazole-based ligands for estrogen-related receptor ? as potential anti-diabetic agents.EBI
Janssen Research And Development
Synthesis, biological evaluation, and molecular docking investigation of benzhydrol- and indole-based dual PPAR-?/FFAR1 agonists.EBI
Suez Canal University
Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of quinazolin-4(3H)-one derivatives as potential PPAR? and SUR agonists.EBI
Al-Azhar University
Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.EBI
Bristol-Myers Squibb
Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR)?/?/? Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate.EBI
Inventiva
Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists.EBI
Bristol-Myers Squibb
Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor?/? (PPAR?/?) dual agonists.EBI
The University Of Tokyo
Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression.EBI
The University Of Tokyo
A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis.EBI
Goethe-University Frankfurt
Polypharmacology of NEBI
Sahmyook University
Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPAR?-Targeted Antidiabetics.EBI
The Scripps Research Institute
Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea.BDB
Kitasato University
Cannabinoid agonist signal transduction in rat brain: comparison of cannabinoid agonists in receptor binding, G-protein activation, and adenylyl cyclase inhibition.BDB
Wake Forest University
Triptolide directly inhibits dCTP pyrophosphatase.BDB
Yale University
Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.BDB
Virginia Commonwealth University
The identification of a novel natural activator of p300 histone acetyltranferase provides new insights into the modulation mechanism of this enzyme.BDB
Universitá
A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry.BDB
University Of Cambridge
Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone.BDB
Queen'S University
The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay.BDB
Pfizer
Characterization of recombinant human serotonin 5HT1A receptors expressed in Chinese hamster ovary cells. [3H]spiperone discriminates between the G-protein-coupled and -uncoupled forms.BDB
University Of Canterbury
[3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments.BDB
Boots Pharmaceuticals
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.BDB
Cnrs
New inhibitors of ABCG2 identified by high-throughput screening.BDB
Saic-Frederick