80 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Green fluorescent protein chromophore derivatives as a new class of aldose reductase inhibitors.
Toho University
Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract.
University Of Colorado
Thiazolidine-2,4-dione derivatives: programmed chemical weapons for key protein targets of various pathological conditions.
Punjabi University
Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold.
Slovak Academy Of Sciences
Targeting aldose reductase for the treatment of diabetes complications and inflammatory diseases: new insights and future directions.
Universit£
20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng.
Kyushu University
Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10.
Gifu Pharmaceutical University
Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors.
Xiangtan University
Synopsis of some recent tactical application of bioisosteres in drug design.
Bristol-Myers Squibb Pharmaceutical Research And Development
Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.
Gifu Pharmaceutical University
Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17ß-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.
University Of Pennsylvania
Optimization of the Central Core of Indolinone-Acetic Acid-Based CRTH2 (DP2) Receptor Antagonists.
TBA
Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives.
Universit£
Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.
Monash University
Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10.
Universitat Aut£Noma De Barcelona
Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.
Aristotle University Of Thessaloniki
Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants.
National Eye Institute
Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.
Wyeth-Ayerst Research
Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors.
Pfizer
A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners.
Pfizer
Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-ß-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1.
University Of Toyama
Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductase.
King'S College London
Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10.
Gifu Pharmaceutical University
Structure-activity relationships of ganoderma acids from Ganoderma lucidum as aldose reductase inhibitors.
Sepuluh Nopember Institute Of Technology
(2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature.
Slovak Academy Of Sciences
Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.
Astrazeneca R&D Charnwood
Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.
Merck Serono
Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
The Institute For Diabetes Discovery
Furoxan nitric oxide donor coupled chrysin derivatives: synthesis and vasculoprotection.
Central South University
In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.
University Of Messina
Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10.
Gifu Pharmaceutical University
Evaluation of aldose reductase inhibition and docking studies of 6'-nitro and 6',6''-dinitrorosmarinic acids.
National Hellenic Research Foundation
Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole.
Aristotle University Of Thessaloniki
Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols.
Central Food Technological Research Institute
Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.
Università
Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.
Monash University (Parkville Campus)
High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor.
Monash University (Parkville Campus)
Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product.
Instituto Biomar
A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.
Rational Drug Design Laboratories
Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment.
University Of Hradec Kralove
Design of an amide N-glycoside derivative of ?-glucogallin: a stable, potent, and specific inhibitor of aldose reductase.
University Of Colorado Anschutz Medical Campus
Synthesis and aldose reductase inhibitory activity of 7-sulfamoylxanthone-2-carboxylic acids.
TBA
New phenolic and quinone-methide triterpenes from Maytenus amazonica.
Universidad De La Laguna
Structures and aldose reductase inhibitory effects of bromophenols from the red alga Symphyocladia latiuscula.
Jilin Province Academy Of Traditional Chinese Medicine And Materia Medica
Synthesis, absolute configuration, and conformation of the aldose reductase inhibitor sorbinil.
TBA
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
TBA
Antiinflammatory and aldose reductase inhibitory activity of some tricyclic arylacetic acids.
TBA
Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity.
Slovak Academy Of Sciences
Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors.
Pfizer
Gossypol and derivatives: a new class of aldose reductase inhibitors.
University Of New Mexico School Of Medicine
1-Acetyl-5-phenyl-1H-pyrrol-3-ylacetate: An aldose reductase inhibitor for the treatment of diabetic nephropathy.
Shanghai Institute Of Pharmaceutical Industry
Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners.
Pfizer
Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain.
Pfizer
Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives.
Pfizer
Biological activities and quantitative structure-activity relationships of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as aldose reductase inhibitors.
Tanabe Seiyaku
Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells.
Gifu Pharmaceutical University