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80 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Green fluorescent protein chromophore derivatives as a new class of aldose reductase inhibitors.EBI
Toho University
Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract.EBI
University Of Colorado
Thiazolidine-2,4-dione derivatives: programmed chemical weapons for key protein targets of various pathological conditions.EBI
Punjabi University
Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold.EBI
Slovak Academy Of Sciences
Targeting aldose reductase for the treatment of diabetes complications and inflammatory diseases: new insights and future directions.EBI
Universit£
20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng.EBI
Kyushu University
Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10.EBI
Gifu Pharmaceutical University
Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors.EBI
Xiangtan University
Synopsis of some recent tactical application of bioisosteres in drug design.EBI
Bristol-Myers Squibb Pharmaceutical Research And Development
Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.EBI
Gifu Pharmaceutical University
Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17ß-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.EBI
University Of Pennsylvania
Optimization of the Central Core of Indolinone-Acetic Acid-Based CRTH2 (DP2) Receptor Antagonists.EBI
TBA
Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives.EBI
Universit£
Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.EBI
Monash University
Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10.EBI
Universitat Aut£Noma De Barcelona
Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.EBI
Aristotle University Of Thessaloniki
Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants.EBI
National Eye Institute
Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.EBI
Wyeth-Ayerst Research
Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors.EBI
Pfizer
A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners.EBI
Pfizer
Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones.EBI
Pfizer
Spiro hydantoin aldose reductase inhibitors.EBI
Pfizer
Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-ß-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1.EBI
University Of Toyama
Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductase.EBI
King'S College London
Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10.EBI
Gifu Pharmaceutical University
Structure-activity relationships of ganoderma acids from Ganoderma lucidum as aldose reductase inhibitors.EBI
Sepuluh Nopember Institute Of Technology
(2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature.EBI
Slovak Academy Of Sciences
Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.EBI
Astrazeneca R&D Charnwood
Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.EBI
Merck Serono
Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.EBI
The Institute For Diabetes Discovery
Furoxan nitric oxide donor coupled chrysin derivatives: synthesis and vasculoprotection.EBI
Central South University
In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.EBI
University Of Messina
6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2.EBI
University Of Toyama
Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10.EBI
Gifu Pharmaceutical University
Evaluation of aldose reductase inhibition and docking studies of 6'-nitro and 6',6''-dinitrorosmarinic acids.EBI
National Hellenic Research Foundation
Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole.EBI
Aristotle University Of Thessaloniki
Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols.EBI
Central Food Technological Research Institute
Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.EBI
Università
Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.EBI
Monash University (Parkville Campus)
High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor.EBI
Monash University (Parkville Campus)
Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product.EBI
Instituto Biomar
A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.EBI
Rational Drug Design Laboratories
Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment.EBI
University Of Hradec Kralove
Design of an amide N-glycoside derivative of ?-glucogallin: a stable, potent, and specific inhibitor of aldose reductase.EBI
University Of Colorado Anschutz Medical Campus
Synthesis and aldose reductase inhibitory activity of 7-sulfamoylxanthone-2-carboxylic acids.EBI
TBA
New phenolic and quinone-methide triterpenes from Maytenus amazonica.EBI
Universidad De La Laguna
Friedelane triterpenoids from Maytenus macrocarpa.EBI
Universidad De Laguna
Structures and aldose reductase inhibitory effects of bromophenols from the red alga Symphyocladia latiuscula.EBI
Jilin Province Academy Of Traditional Chinese Medicine And Materia Medica
Synthesis, absolute configuration, and conformation of the aldose reductase inhibitor sorbinil.EBI
TBA
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.EBI
TBA
Antiinflammatory and aldose reductase inhibitory activity of some tricyclic arylacetic acids.EBI
TBA
Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity.EBI
Slovak Academy Of Sciences
Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors.EBI
Pfizer
An overview of benzo[b]thiophene-based medicinal chemistry.EBI
Jain University
Lipophilic Efficiency as an Important Metric in Drug Design.EBI
Pfizer
Gossypol and derivatives: a new class of aldose reductase inhibitors.EBI
University Of New Mexico School Of Medicine
1-Acetyl-5-phenyl-1H-pyrrol-3-ylacetate: An aldose reductase inhibitor for the treatment of diabetic nephropathy.EBI
Shanghai Institute Of Pharmaceutical Industry
Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners.EBI
Pfizer
Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain.EBI
Pfizer
Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives.EBI
Pfizer
Biological activities and quantitative structure-activity relationships of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as aldose reductase inhibitors.EBI
Tanabe Seiyaku
Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells.EBI
Gifu Pharmaceutical University
New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.BDB
Alexandria University