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88 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors.EBI
Shandong University
Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains.EBI
Shandong University
Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites.EBI
China Pharmaceutical University
Structural modification of luteolin from Flos Chrysanthemi leads to increased tumor cell growth inhibitory activity.EBI
Second Military Medical University
Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity.EBI
Astrazeneca
Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods.EBI
Vanderbilt University School Of Medicine
Peptide-based inhibitors of protein-protein interactions.EBI
Wroclaw University Of Technology
Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors.EBI
Shandong University
Design, synthesis and biological evaluation of 3-aryl-rhodanine benzoic acids as anti-apoptotic protein Bcl-2 inhibitors.EBI
Shandong University
Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design.EBI
Vanderbilt University School Of Medicine
Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.EBI
Abbvie
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents.EBI
Universit£
Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors.EBI
Shandong University
A combination of in silico and SAR studies to identify binding hot spots of Bcl-xL inhibitors.EBI
Bioprojet-Biotech
Towards the next generation of dual Bcl-2/Bcl-xL inhibitors.EBI
Astrazeneca
A simple and widely applicable hit validation strategy for protein-protein interaction inhibitors based on a quantitative ligand displacement assay.EBI
Takeda Pharmaceutical
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.EBI
Abbvie
Endiandric acid analogues from Beilschmiedia ferruginea as dual inhibitors of Bcl-xL/Bak and Mcl-1/Bid interactions.EBI
Institut De Chimie Des Substances Naturelles (Icsn)
Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.EBI
Genentech
3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.EBI
University Of Michigan Medical School
Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.EBI
Eutropics Pharmaceuticals
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.EBI
The Walter And Eliza Hall Institute Of Medical Research
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach.EBI
Dalian University Of Technology
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.EBI
University Of Michigan
The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions.EBI
Novartis Institutes For Biomedical Research
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.EBI
Vanderbilt University School Of Medicine
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1.EBI
Dalian University Of Technology
3D-QSAR pharmacophore modeling and in silico screening of new Bcl-xl inhibitors.EBI
Universit£
Synthesis and biological activities of polyquinoline derivatives: new Bcl-2 family protein modulators.EBI
Clermont Universit£
Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.EBI
University Of Michigan
Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold.EBI
University Of Michigan
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists.EBI
Bristol-Myers Squibb Research
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.EBI
Bristol-Myers Squibb Research
Unbiased binding assays for discovering small-molecule probes and drugs.EBI
Broad Institute Of Harvard And Mit
BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.EBI
Sanford-Burnham Medical Research Institute
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues.EBI
University Of Minnesota
Fragment-based drug discovery.EBI
Sunesis Pharmaceuticals
Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.EBI
Institute
Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.EBI
Second Military Medical University
Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.EBI
University Of Washington
SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.EBI
Sanford-Burnham Medical Research Institute
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.EBI
The Walter And Eliza Hall Institute Of Medical Research
Anti-tumor pyrimidinylpiperazines bind to the prosurvival Bcl-2 protein family member Bcl-XL.EBI
University Of The Pacific
Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.EBI
Sanford-Burnham Medical Research Institute
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.EBI
Aristotle University Of Thessaloniki
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.EBI
Abbott Laboratories
Rearranged diterpenoids from the biotransformation of ent-trachyloban-18-oic acid by Rhizopus arrhizus.EBI
Centre De Recherche De Gif
Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.EBI
Chinese Academy Of Sciences
Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention.EBI
Institute For Medical Research
Fragment-based deconstruction of Bcl-xL inhibitors.EBI
Universite De Lyon
Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1.EBI
Institute Of Chemical And Engineering Sciences
Cytotoxic pentacyclic triterpenoids from Combretum sundaicum and Lantana camara as inhibitors of Bcl-xL/BakBH3 domain peptide interaction.EBI
Cnrs
A Dimeric sesquiterpenoid from a Malaysian Meiogyne as a new inhibitor of Bcl-xL/BakBH3 domain peptide interaction.EBI
Cnrs
Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl.EBI
Merlion Pharmaceuticals
Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2.EBI
Infinity Pharmaceuticals
Structure-activity relationships of Bak derived peptides: affinity and specificity modulations by amino acid replacement.EBI
University Of Montpellier
Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer.EBI
University Of Minnesota
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.EBI
University Of Michigan
Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.EBI
Abbott Laboratories
Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein.EBI
Yale University
Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors.EBI
Shandong University
Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein.EBI
Soochow University
Identification of lead compounds as antagonists of protein Bcl-xL with a diversity-oriented multidisciplinary approach.EBI
Universita Degli Studi Di Salerno
Development of high potent and selective Bcl-2 inhibitors bearing the structural elements of natural product artemisinin.EBI
Shanghai Institute Of Materia Medica (Simm)
Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection.EBI
Abbvie
Design, synthesis and pharmacological evaluation of new acyl sulfonamides as potent and selective Bcl-2 inhibitors.EBI
Shanghai Institute Of Materia Medica (Simm)
Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A.EBI
Universit£
Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents.EBI
Hunan Provinc
Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules.EBI
University Of Maryland
1-Phenyl-1H-indole derivatives as a new class of Bcl-2/Mcl-1 dual inhibitors: Design, synthesis, and preliminary biological evaluation.EBI
Shandong University
Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design.EBI
Vanderbilt University School Of Medicine
Cytotoxicity and topoisomerase I/II inhibition activity of novel 4-aryl/alkyl-1-(piperidin-4-yl)-carbonylthiosemicarbazides and 4-benzoylthiosemicarbazides.BDB
Medical University
Potential of pyrazolooxadiazinone derivatives as serine protease inhibitors.BDB
UniversitÀ
Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.BDB
Merck Research Laboratories
Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719.BDB
Smithkline Beecham Pharmaceuticals
In vitro pharmacological profile of a novel structural class of oxytocin antagonists.BDB
Merck Sharp & Dohme Research Laboratories
Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes.BDB
Merck Research Laboratories