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36 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178.EBI
Mahidol University
Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase anda-Glucosidase.EBI
Chinese Academy Of Sciences
Molecular modeling studies of atorvastatin analogues as HMGR inhibitors using 3D-QSAR, molecular docking and molecular dynamics simulations.EBI
Shanghai Institute Of Technology
Synthesis and highly potent hypolipidemic activity of alpha-asarone- and fibrate-based 2-acyl and 2-alkyl phenols as HMG-CoA reductase inhibitors.EBI
Instituto Polit£Cnico Nacional (Ipn)
Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.EBI
National Taiwan University
Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones.EBI
Institute Of Pharmaceutical Industry
Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA).EBI
National Institute Of Pharmaceutical Education And Research (Niper)
Synthesis and biological evaluation of dihydroeptastatin, a novel inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.EBI
British Bio-Technology
Inhibitors of cholesterol biosynthesis. 6. trans-6-[2-(2-N-heteroaryl-3,5-disubstituted- pyrazol-4-yl)ethyl/ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones.EBI
Warner-Lambert
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.EBI
Hoechst
Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent.EBI
Central Drug Research Institute (Csir)
Peptide fragmentation as an approach in modeling of an active peptide and designing a competitive inhibitory peptide for HMG-CoA reductase.EBI
Institute Of The Chemistry Of Plant Substances
 
Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of 3-Hydroxy-3-methyl-glutaryl Coenzyme A ReductaseEBI
TBA
 
Synthesis of tetrazol-1-yl analogs of HMG-COA reductase inhibitor BMS180431 (formerly BMY21950)EBI
TBA
 
Phosphinic acid inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme a reductaseEBI
TBA
Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.EBI
Pfizer
Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.EBI
Pfizer
Molecular docking of the highly hypolipidemic agent alpha-asarone with the catalytic portion of HMG-CoA reductase.EBI
Universidad Nacional AutóNoma De MéXico
Synthesis and biological evaluations of condensed pyridine and condensed pyrimidine-based HMG-CoA reductase inhibitors.EBI
Central Research Institute
Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols.EBI
The University Of Tokyo
Bipolaricins A-I, Ophiobolin-Type Tetracyclic Sesterterpenes from a Phytopathogenic EBI
Huazhong University Of Science And Technology
Why Some Targets Benefit from beyond Rule of Five Drugs.EBI
Boston University
32-Methyl-32-oxylanosterols: dual-action inhibitors of cholesterol biosynthesis.EBI
Institute
Design and synthesis of seco-oxysterol analogs as potential inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase gene transcription.EBI
Upjohn Laboratories
Synthesis of a novel lysophosphatidylcholine.EBI
Graduate School Of Okayama University
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids.EBI
Hoechst
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids.EBI
Hoechst
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.EBI
St. John'S University
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs.EBI
Merck Research Laboratories
Discovery of potent and reversible monoacylglycerol lipase inhibitors.BDB
University Of California Irvine
Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD.BDB
Burnham Institute For Medical Research
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.BDB
Pfizer