The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.8M data for 1.2M Compounds and 9.2K Targets. Of those, 1,346K data for 622K Compounds and 4.5K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

Advanced Search

50 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Part-1: Design, synthesis and biological evaluation of novel bromo-pyrimidine analogs as tyrosine kinase inhibitors.EBI
Rallis India
Discovery of 3-(5'-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation.EBI
East China University Of Science & Technology
Rational Design, Synthesis, and Biological Evaluation of 7-Azaindole Derivatives as Potent Focused Multi-Targeted Kinase Inhibitors.EBI
Oribase Pharma
Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.EBI
Experimental Therapeutics Centre
Expanding the structural diversity of Bcr-Abl inhibitors: Dibenzoylpiperazin incorporated with 1H-indazol-3-amine.EBI
First Affiliated Hospital Of Xi'An Jiaotong University
Expanding the structural diversity of Bcr-Abl inhibitors: Hybrid molecules based on GNF-2 and Imatinib.EBI
Xi'An Jiaotong University
Synthesis and biological evaluation of novel aromatic-heterocyclic biphenyls as potent anti-leukemia agents.EBI
Xi'An Jiaotong University
Hybrid pyrimidine alkynyls inhibit the clinically resistance related Bcr-Abl(T315I) mutant.EBI
Guangzhou Institutes Of Biomedicine And Health
Imatinib analogs as potential agents for PET imaging of Bcr-Abl and c-KIT expression at a kinase level.EBI
The University Of Texas M.D. Anderson Cancer Center
The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588.EBI
Novartis Institutes For Biomedical Research
Design, synthesis and biological activities of Nilotinib derivates as antitumor agents.EBI
Xi'An Jiaotong University
BCR-ABL tyrosine kinase inhibitor pharmacophore model derived from a series of phenylaminopyrimidine-based (PAP) derivatives.EBI
The First People'S Hospital Of Hangzhou
Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities.EBI
University Of Nottingham
Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)¿isoleucine(315) mutant.EBI
Chinese Academy Of Sciences
Features of selective kinase inhibitors.EBI
University Of California San Francisco
Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach.EBI
University Of South Florida
3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors.EBI
Chiron
Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.EBI
Universit£
Hybrid compounds as new Bcr/Abl inhibitors.EBI
Chinese Academy Of Sciences
Expanding the diversity of allosteric bcr-abl inhibitors.EBI
Harvard Medical School
Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib.EBI
Novartis Institutes For Biomedical Research
Design, synthesis and evaluation of (E)-alpha-benzylthio chalcones as novel inhibitors of BCR-ABL kinase.EBI
Temple University School Of Medicine
Allosteric inhibitors of Bcr-abl-dependent cell proliferation.EBI
Genomics Institute Of The Novartis Research Foundation
Selectively nonselective kinase inhibition: striking the right balance.EBI
Schering-Plough
Structural insights into the ATP binding pocket of the anaplastic lymphoma kinase by site-directed mutagenesis, inhibitor binding analysis, and homology modeling.EBI
University Of Milano-Bicocca
Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase.EBI
University Of Regensburg
Design and synthesis of 5-aryl-pyridone-carboxamides as inhibitors of anaplastic lymphoma kinase.EBI
Chembridge Research Laboratories And Chembridge
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.EBI
Bristol-Myers Squibb Pharmaceutical Research Institute
Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-EBI
The Genomics Institute Of The Novartis Research Foundation
Design, synthesis, and biological evaluations of novel 3-amino-4-ethynyl indazole derivatives as Bcr-Abl kinase inhibitors with potent cellular antileukemic activity.EBI
Korea Institute Of Science And Technology (Kist)
Design, synthesis, and biological activity of 4-(imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl-phenylbenzamide derivatives as BCR-ABL kinase inhibitors.EBI
Beijing University Of Technology
Medicinal Chemistry Strategies for the Development of Kinase Inhibitors Targeting Point Mutations.EBI
Jinan University
Efficacy and Tolerability of Pyrazolo[1,5-EBI
The Genomics Institute Of The Novartis Research Foundation
Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90-Kinase Interactions.EBI
Chinese Academy Of Sciences
Structure-based analysis and biological characterization of imatinib derivatives reveal insights towards the inhibition of wild-type BCR-ABL and its mutants.EBI
Peking Union Medical College And Chinese Academy Of Medical Sciences
Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases.EBI
University Of California
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia.EBI
Chinese Academy Of Sciences
Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361).EBI
Athenex
Discovery of novel Bcr-AblEBI
Xi'An Jiaotong University
Design and Optimization of 3'-(Imidazo[1,2-EBI
Jinan University
Development of Alkyne-Containing Pyrazolopyrimidines To Overcome Drug Resistance of Bcr-Abl Kinase.EBI
University Of Southern California
Discovery of novel Bcr-Abl inhibitors targeting myristoyl pocket and ATP site.EBI
Xi'An Jiaotong University
Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors.EBI
Chinese Academy Of Sciences
ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups.EBI
Vertex Pharmaceuticals
Effects of rigidity on the selectivity of protein kinase inhibitors.EBI
University Of Southern California
Design and synthesis of novel dasatinib derivatives as inhibitors of leukemia stem cells.EBI
Tianjin International Joint Academy Of Biomedicine
Brain penetrant kinase inhibitors: Learning from kinase neuroscience discovery.EBI
Eli Lilly
Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.EBI
Jinan University
F-NMR-Based Dual-Site Reporter Assay for the Discovery and Distinction of Catalytic and Allosteric Kinase Inhibitors.EBI
Novartis Institutes For Biomedical Research