PMID

Data

Article Title

Organization

Specific inhibition of HIV-1 protease by boronated porphyrins.

University Of California

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.

Parke-Davis Pharmaceutical Research Division Of Warner-Lambert

Design of rat renin inhibitory peptides.

Massachusetts General Hospital

Design, structure-activity, and molecular modeling studies of potent renin inhibitory peptides having N-terminal Nin-For-Trp (Ftr): angiotensinogen congeners modified by P1-P1' Phe-Phe, Sta, Leu psi[CH(OH)CH2]Val or leu psi[CH2NH]Val substitutions.

Upjohn

Pepstatin analogues as novel renin inhibitors.

TBA

Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine.

TBA

Direct renin inhibitors as a new therapy for hypertension.

Novartis Pharmaceuticals

The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin.

Nagasaki International University

 

Novel low molecular renin inhibitors which show good oral blood pressure lowering effects in marmosets

TBA

 

CP-71,362, an unusually potent inhibitor of rat and dog renin

TBA

 

Evaluation of the intestinal permeability and hepatic handling of peptidomimetic analogs

TBA

 

MDL 74147, a novel selective and soluble inhibitor of human renin. Synthesis, structure-activity relationship, species and protease selectivities.

TBA

The discovery of structurally novel CCR1 antagonists derived from a hydroxyethylene peptide isostere template.

Pfizer

Studies directed toward the design of orally active renin inhibitors. 2. Development of the efficacious, bioavailable renin inhibitor (2S)-2-benzyl-3- [[(1-methylpiperazin-4-yl)sulfonyl]propionyl]-3-thiazol-4-yl-L-alanine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (A-725

Abbott Laboratories

Renin inhibitors containing a pyridyl amino diol derived C-terminus.

Hoechst

Nonpeptide renin inhibitors with good intraduodenal bioavailability and efficacy in dog.

Abbott Laboratories

Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond.

Abbott Laboratories

Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides.

TBA

Synthesis and biological activity of some transition-state inhibitors of human renin.

Ciba-Geigy

New human renin inhibitors containing an unnatural amino acid, norstatine.

Kissei Pharmaceutical

Inhibitors of human renin. Cyclic peptide analogues containing a D-Phe-Lys-D-Trp sequence.

Ici Pharmaceuticals Group

Potent renin inhibitory peptides containing hydrophilic end groups.

Upjohn

Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.

Takeda Pharmaceutical

Renin inhibitory pentols showing improved enteral bioavailability.

Hoechst