PMID

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Article Title

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Discovery of novel indole derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase.

Chinese Academy Of Medical Sciences & Peking Union Medical College

Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase.

Chinese Academy Of Medical Sciences & Peking Union Medical College

Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase.

Metabasis Therapeutics

Discovery of potent and orally active tricyclic-based FBPase inhibitors.

Daiichi Sankyo

Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines.

Pfizer

Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.

F. Hoffmann-La Roche

Designing inhibitors against fructose 1,6-bisphosphatase: exploring natural products for novel inhibitor scaffolds.

Boston College

Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors.

Daiichi Sankyo

Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.

F. Hoffmann-La Roche

Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics.

Metabasis Therapeutics

Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors.

Daiichi Sankyo

A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase.

Boston College

Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics.

Metabasis Therapeutics

Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites.

F. Hoffmann-La Roche

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase.

Abbott Laboratories

Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase.

University Of Porto

Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction.

Central China Normal University

Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects.

International Cooperation Base Of Pesticide And Green Synthesis (Hubei)