BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 756K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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22 articles for K James

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Molecular hybridization yields triazole bronchodilators for the treatment of COPD.EBI
Pfizer
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.EBI
The Institute of Cancer Research
The discovery of long acting beta2-adrenoreceptor agonists.EBI
Pfizer
The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds.EBI
Kingston University
Inhibition of estrone sulfatase (ES) by derivatives of 4-[(aminosulfonyl)oxy] benzoic acid.EBI
Kingston University
Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES).EBI
Kingston University
Acid dissociation constant, a potential physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES).EBI
Kingston University
Novel inhibitors of the enzyme estrone sulfatase (ES).EBI
Kingston University
Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism.EBI
Kingston University
Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES).EBI
Kingston University
Derivation of a possible transition-state for the reaction catalysed by the enzyme estrone Sulfatase (ES).EBI
Kingston University
Inhalation by design: novel tertiary amine muscarinic M3 receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.EBI
Pfizer
Inhalation by design: dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD.EBI
Pfizer
Inhalation by design: novel ultra-long-actingß(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup.EBI
Pfizer
 
Gem-cycloalkyl substituted thiol inhibitors of neutral endopeptidase 24.11. Synthesis via nucleophilic opening of 2,2-spiro-β-lactonesEBI
TBA
 
Adenosine-2′-monophosphate derivatives: Structural requirements as substrates for inositol monophosphataseEBI
TBA
Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents.EBI
Pfizer
Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.EBI
Pfizer
Design of selective thrombin inhibitors based on the (R)-Phe-Pro-Arg sequence.EBI
Pfizer
The design and synthesis of a novel series of indole derived selective ET(A) antagonists.EBI
Pfizer
Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.EBI
Pfizer
Factor xia-inhibiting pyridobenzazepine and pyridobenzazocine derivativesBDB
Bayer Pharma Aktiengesellschaft