The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.5M data for 737K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

27 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery of Selective Small-Molecule Inhibitors for theß-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety.EBI
University of Utah
Hot spot-based design of small-molecule inhibitors for protein-protein interactions.EBI
University of Utah
Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists ofß-catenin/TCF transcription.EBI
University of Michigan
Direct targeting ofß-catenin: Inhibition of protein-protein interactions for the inactivation of Wnt signaling.EBI
Chemical Genomics Centre of The Max Planck Society
Design, synthesis, and biological evaluation of novel 8-substituted quercetin derivatives targeting the β‑catenin/B-cell lymphoma 9 interaction.EBI
Tongji University
Design, synthesis and biological evaluation of quercetin derivatives as novel β-catenin/B-cell lymphoma 9 protein-protein interaction inhibitors.EBI
Fudan University
Recent advances of β-catenin small molecule inhibitors for cancer therapy: Current development and future perspectives.EBI
Sichuan University
Discovery of Novel 3-Phenylpiperidine Derivatives Targeting the β-Catenin/B-Cell Lymphoma 9 Interaction as a Single Agent and in Combination with the Anti-PD-1 Antibody for the Treatment of Colorectal Cancer.EBI
Fudan University
Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer.EBI
Ocean University of China
Targeting the interaction of β-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling.EBI
Vu University Amsterdam
Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale.EBI
University of Southampton
Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.EBI
H. Lee Moffitt Cancer Center and Research Institute
Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction.EBI
H. Lee Moffitt Cancer Center and Research Institute
Structure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction Inhibitors.EBI
University of Utah
Target β-catenin/CD44/Nanog axis in colon cancer cells by certain N'-(2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazides.EBI
King Saud University
PIPERAZINYLSULFONYLARYL COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONSBDB
Hoffmann-La Roche
Substituted heterocyclic fused cyclic compound, preparation method therefor and pharmaceutical use thereofBDB
Genfleet Therapeutics (Shanghai)Inc.
NOVEL N-ACYL-[3-SUBSTITUTED]-[8-SUBSTITUTED]-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERSBDB
Ogeda
COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITYBDB
Case Western Reserve University
Indole carboxamide compoundsBDB
Bristol-Myers Squibb
Benzisoxazole derivativeBDB
Sumitomo Pharma
Purinones as ubiquitin-specific protease 1 inhibitorsBDB
Forma Therapeutics
β- and γ-diketones and γ-hydroxyketones as Wnt/β-catenin signaling pathway activatorsBDB
Samumed
Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactionsBDB
University of Utah
Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amineBDB
Nektar Therapeutics
Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactionsBDB
University of Utah
2-aminoimidazole beta-secretase inhibitors for the treatment of alzheimer's diseaseBDB
Merck Sharp & Dohme