BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.5M data for 737K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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27 articles for PR Guzzo

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.EBI
Amri
The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties.EBI
Amri
The discovery of diazepinone-based 5-HT3 receptor partial agonists.EBI
Amri
Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1.EBI
Amri
Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists.EBI
Amri
5-Functionalized indazoles as glucocorticoid receptor agonists.EBI
Amri
Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists.EBI
Amri
Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of ObesityEBI
TBA
Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome.EBI
Amri
5-(pyridinon-1-yl)indazoles and 5-(furopyridinon-5-yl)indazoles as MCH-1 antagonists.EBI
Amri
Tetrahydrocarboline analogs as MCH-1 antagonists.EBI
Amri
Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones as MCH-1 antagonists for the treatment of obesity.EBI
Amri
Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.EBI
Amri
Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.EBI
Merck Research Laboratories
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.EBI
Merck Research Laboratories
Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1.EBI
Amri
Benzene or thiophene derivative and use thereof as VAP-1 inhibitorBDB
R-Tech Ueno
Erythromycin derivatives ABT 229 and GM 611 act on motilin receptors in the rabbit duodenum.BDB
University of Melbourne
Rat alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: pharmacology of ligand binding and function.BDB
Georgetown University
Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding.BDB
Roche Bioscience
BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats.BDB
Smithkline Beecham Pharmaceuticals
PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties.BDB
Pharmacia & Upjohn
The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors.BDB
Max-Planck-Institut FÜR Kohlenforschung
A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression.BDB
Gpc Biotech