22 articles for MG Perrone
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
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Article Title
Organization
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model.
University of Bari Aldo Moro
SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein.
University of Bari Aldo Moro
SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity.
University of Pisa
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments.
University of Bari Aldo Moro
Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.
University of Bari Aldo Moro
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters.
University of Bari Aldo Moro
Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.
University of Bari Aldo Moro
Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.
University of Bari Aldo Moro
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.
University of Bari Aldo Moro
Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers.
University of Florence
A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior.
University of Bari "Aldo Moro"
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid.
University of Bari "Aldo Moro
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein.
University of Turin
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability.
University of Bari "Aldo Moro
Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells.
University of Turin
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators.
University of Florence
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers.
University of Florence
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles.
University of Bari "A. Moro
Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors.
University of Bari Aldo Moro
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier.
University of Bari "Aldo Moro
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).
Thomas Jefferson University
CULLIN-RING E3 UBIQUITIN LIGASE 4 INHIBITOR COMPOUNDS AND METHODS OF THEIR USE
Icahn School Of Medicine At Mount Sinai