61 articles for A Kumar
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How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
Guru Jambheshwar University of Science and Technology
2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling.
University of Cagliari
Novel Imbricatolic acid derivatives as protein tyrosine phosphatase-1B inhibitors: Design, synthesis, biological evaluation and molecular docking.
University of Lucknow
Identification of new SUMO activating enzyme 1 inhibitors using virtual screening and scaffold hopping.
Riken
Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents.
India Academy of Scientific & Innovative Research (Acsir)
Design, synthesis and biological evaluation ofß-boswellic acid based HDAC inhibitors as inducers of cancer cell death.
Csir-Indian Institute of Integrative Medicine
Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines asa7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders.
Critical Therapeutics
Methyl-thiazoles: a novel mode of inhibition with the potential to develop novel inhibitors targeting InhA in Mycobacterium tuberculosis.
Astrazeneca India
Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors.
Riken
Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice.
Central Drug Research Institute
Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties.
The Johns Hopkins University School of Medicine
Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibitors.
University of Rhode Island
Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents.
University of Messina
Design and synthesis of phosphonate inhibitors of glutamine synthetase.
Pennsylvania State University
One-pot regioselective synthesis of tetrahydroindazolones and evaluation of their antiproliferative and Src kinase inhibitory activities.
Birla Institute of Technology
Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents.
Central Drug Research Institute
3-substitued indoles: one-pot synthesis and evaluation of anticancer and Src kinase inhibitory activities.
India Institute of Technology and Science
Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities.
Institute of Technology and Science
Click chemistry inspired one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles and their Src kinase inhibitory activity.
Institute of Technology and Science
Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents.
Central Drug Research Institute
Pyranocoumarins: a new class of anti-hyperglycemic and anti-dyslipidemic agents.
Central Drug Research Institute
Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography.
The Johns Hopkins University School of Medicine
Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities.
Central Drug Research Institute
Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease.
Indian Institute of Technology (Banaras Hindu University)
Synthesis of thiazolidine-2,4-dione tethered 1,2,3-triazoles as α-amylase inhibitors: In vitro approach coupled with QSAR, molecular docking, molecular dynamics and ADMET studies.
Kurukshetra University
Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin-3 Comprising 2-Methyl-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione.
Bristol Myers Squibb
Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling.
An-Najah National University
Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator.
Max Planck Institute of Molecular Physiology
Ligand based virtual screening and biological evaluation of inhibitors of chorismate mutase (Rv1885c) from Mycobacterium tuberculosis H37Rv.
Central Drug Research Institute
MEK inhibitors in cancer treatment: structural insights, regulation, recent advances and future perspectives.
Central University of Punjab
Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies.
Guru Jambheshwar University of Science and Technology
Design and evaluation of hydroxamate derivatives as metal-mediated inhibitors of a protein tyrosine kinase.
University of Rhode Island
Engagement of phytoestrogens in breast cancer suppression: Structural classification and mechanistic approach.
Central University of Punjab
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
Bristol-Myers Squibb
Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents.
Central Drug Research Institute
Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors.
Bristol Myers Squibb
Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
Bristol Myers Squibb Research and Early Development
Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.
University of Cape Town
Identification of dual role of piperazine-linked phenyl cyclopropyl methanone as positive allosteric modulator of 5-HT
Csir-Central Drug Research Institute (Csir-Cdri)
Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease.
Indian Institute of Technology (Banaras Hindu University)
Novel Tetrahydroquinazolinamines as Selective Histamine 3 Receptor Antagonists for the Treatment of Obesity.
Academy of Scientific and Innovative Research (Acsir)
A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors.
Dalian University of Technology
Natural products as multidrug resistance modulators in cancer.
Central University of Punjab
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Csir-Central Drug Research Institute
Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083).
Cleave Biosciences
Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship.
Csir-Indian Institute of Integrative Medicine
Designing novel inhibitors against histone acetyltransferase (HAT: GCN5) of Plasmodium falciparum.
Jawaharlal Nehru University
Discovery of coumarin-dihydroquinazolinone analogs as niacin receptor 1 agonist with in-vivo anti-obesity efficacy.
Csir-Central Drug Research Institute
Identification of novel β-lactams and pyrrolidinone derivatives as selective Histamine-3 receptor (H3R) modulators as possible anti-obesity agents.
Csir-Central Drug Research Institute
Benzofurans as mechanism-based inhibitors of dopamine beta-hydroxylase.
Pennsylvania State University
Design and synthesis of bis(indolyl)ketohydrazide-hydrazones: Identification of potent and selective novel tubulin inhibitors.
Birla Institute of Technology
Exploring Derivatives of Quinazoline Alkaloid l-Vasicine as Cap Groups in the Design and Biological Mechanistic Evaluation of Novel Antitumor Histone Deacetylase Inhibitors.
Csir-Indian Institute of Integrative Medicine
Pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2
Hoffmann-La Roche
Compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same
Lg Life Sciences
Amino and carboxy functionalized modified nucleosides: a potential class of inhibitors for angiogenin.
Sastra University
Substituted 3-(1H-benzo[d]imidazol-2-yl)-1H-indazole analogs as inhibitors of the PDK1 kinase
University of Utah