BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 745K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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13 articles for DL McMinn

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.EBI
Amgen
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.EBI
Amgen
Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11ß-HSD1 inhibitors.EBI
Amgen
Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.EBI
Amgen
Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit.EBI
Amgen
Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11ß-HSD1 inhibitors.EBI
Amgen
Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.EBI
Amgen
Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists.EBI
Amgen
Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide).EBI
Kezar Life Sciences
Discovery of a Highly Selective STK16 Kinase Inhibitor.BDB
Chinese Academy of Sciences
Inhibition of arginine aminopeptidase by bestatin and arphamenine analogues. Evidence for a new mode of binding to aminopeptidases.BDB
University of Wisconsin
Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB.BDB
Leiden University
Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease.BDB
National Taiwan University