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67 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

Article Title
Identification of potent and selective retinoic acid receptor gamma (RAR) antagonists for the treatment of osteoarthritis pain using structure based drug design.EBI
Eli Lilly and Company
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR Inhibitor.EBI
Central Pharmaceutical Research Institute
Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-a agonistic activity.EBI
Aichi Gakuin University
Small molecule inhibitors targeting activator protein 1 (AP-1).EBI
University of Texas Medical Branch
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for ROR and RORt.EBI
Phenex Pharmaceuticals AG
Inhibition of IB kinase- and IB kinase-a by heterocyclic adamantyl arotinoids.EBI
Universidade de Vigo
Design, synthesis and evaluation of retinoids with novel bulky hydrophobic partial structures.EBI
Research Foundation Itsuu Laboratory
Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands.EBI
ACADIA Pharmaceuticals AB
Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents.EBI
Johnson & Johnson Pharmaceutical Research and Development LLC
Synthesis and biological activities of new heterocyclic aromatic retinoidsEBI
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.EBI
Aristotle University of Thessaloniki
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.EBI
Phenex Pharmaceuticals AG
Identification of a chromone-based retinoid containing a polyolefinic side chain via facile synthetic routes.EBI
Temple University
Synthesis and structure-activity relationships of potent conformationally restricted retinoid X receptor ligandsEBI
Synthesis and structure-activity relationships of potent retinoid X receptor ligandsEBI
Synthesis and biological activity of 1,2,3,4-tetrahydroquinoline and 3,4-(1H)-dihydroquinolin-2-one analogs of retinoic acidEBI
Synthesis and receptor binding affinity of conformationally restricted retinoic acid analoguesEBI
Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostereEBI
Synthesis and pharmacological activity of conformationally restricted, acetylenic retinoid analogsEBI
Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acidsEBI
Structural basis for the differential RXR & RAR activity of stilbene retinoid analogsEBI
Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.EBI
University of Lille
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.EBI
University of Maryland
Structure-based design of potent retinoid X receptor alpha agonists.EBI
Design, synthesis and structure-activity relationship of novel RXR-selective modulators.EBI
Ligand Pharmaceuticals Inc
Design and synthesis of novel RXR-selective modulators with improved pharmacological profile.EBI
Ligand Pharmaceuticals Inc
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid.EBI
Ligand Pharmaceuticals Inc
Synthesis and biological activity of retinoic acid receptor-alpha specific amides.EBI
Allergan Inc
Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.EBI
Allergan Inc
Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor alpha antagonists.EBI
Eisai Co., Ltd
Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity.EBI
Allergan Inc
Syntheses and evaluation of naphthalenyl- and chromenyl-pyrrolyl-benzoic acids as potent and selective retinoic acid receptor alpha agonists.EBI
Eisai Co., Ltd
Novel retinoic acid receptor alpha agonists: syntheses and evaluation of pyrazole derivatives.EBI
Eisai Co., Ltd
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.EBI
Goethe University Frankfurt
Syntheses and structure-activity relationships of 5,6,7, 8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxaline derivatives with retinoic acid receptor alpha agonistic activity.EBI
Eisai Co., Ltd
Structure-activity relationship studies of novel heteroretinoids: induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid.EBI
Università di Ferrara
Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors.EBI
University of Oklahoma Health Sciences Center
Synthesis, structure-activity relationships, and RARgamma-ligand interactions of nitrogen heteroarotinoids.EBI
University of Oklahoma Health Sciences Center
A new class of potent RAR antagonists: dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids.EBI
Allergan Inc
Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands.EBI
Allergan Inc
High affinity retinoic acid receptor antagonists: analogs of AGN 193109.EBI
Allergan Inc
Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells.EBI
Ligand Pharmaceuticals Inc
Synthesis and characterization of heteroarotinoids demonstrate structure specificity relationships.EBI
University of Oklahoma Health Sciences Center
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.EBI
University of Tokyo
Identification of retinoic acid receptor beta subtype specific agonists.EBI
Allergan Inc
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.EBI
Allergan Inc
Identification of the first retinoid X, receptor homodimer antagonist.EBI
Ligand Pharmaceuticals Inc
Identification of a retinoic acid receptor alpha subtype specific agonist.EBI
Allergan Inc
Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.EBI
Ligand Pharmaceuticals Inc
Retinoic acid receptor beta,gamma-selective ligands: synthesis and biological activity of 6-substituted 2-naphthoic acid retinoids.EBI
Pharmaceutical Research Institute
Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes.EBI
Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.EBI
SRI International
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties.EBI
Ligand Pharmaceuticals Inc
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.EBI
Ligand Pharmaceuticals Inc
Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.EBI
SRI International
Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids.EBI
Allergan Inc
Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors.EBI
Allergan Inc
Identification of highly potent retinoic acid receptor alpha-selective antagonists.EBI
Allergan Inc
Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids.EBI
Helwan University
Structure-based design of Trifarotene (CD5789), a potent and selective RAR? agonist for the treatment of acne.EBI
Nestle Skin Health
Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist.EBI
King's College
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.EBI
St. John's University
[(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), a highly potent and selective agonist of the nociceptin/orphanin FQ receptor.BDB
Section of Pharmacology
Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding.BDB
Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.BDB
Institute of Genetics and Molecular and Cellular Biology (IGBMC)
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.BDB
Bristol-Myers Squibb Co.