Binding Database

BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 745K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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11 articles for RV Connors

The following articles (labelled with PubMed ID or TBD) are for your review

PMID

Data

Article Title

Organization

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.

Amgen

Discovery and optimization of a novel Neuromedin B receptor antagonist.

Amgen

3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors

Merck Sharp & Dohme

Bicyclic heteroaryl substituted compounds

Bristol-Myers Squibb

Therapeutic compounds, compositions and methods of use thereof

Genentech

Structure of REV-ERBß ligand-binding domain bound to a porphyrin antagonist.

The Scripps Research Institute

The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity.

Harvard Neurodiscovery Center

New cholinesterase inhibitors for Alzheimer's disease: Structure Activity Studies (SARs) and molecular docking of isoquinolone and azepanone derivatives.

Universidade De Evora

Discovery of a Highly Selective STK16 Kinase Inhibitor.

Chinese Academy of Sciences

Inhibition of arginine aminopeptidase by bestatin and arphamenine analogues. Evidence for a new mode of binding to aminopeptidases.

University of Wisconsin

Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB.

Leiden University