27 articles for Y Sato
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.
Shionogi
Development of stapled short helical peptides capable of inhibiting vitamin D receptor (VDR)-coactivator interactions.
National Institute of Health Sciences
Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125).
Shionogi
Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors.
Takeda Pharmaceutical
Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation.
TBA
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.
Takeda Pharmaceutical
Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin D nuclear receptor.
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors.
Dainippon Sumitomo Pharma
Synthesis and structure-activity relationships of N-aryl-piperidine derivatives as potent (partial) agonists for human histamine H3 receptor.
Meiji Seika Kaisha
(2S,2'R)-analogue of LG190178 is a major active isomer.
National Institute of Health Sciences
Benzoxazole derivatives as novel 5-HT3 receptor partial agonists in the gut.
Pharmaceutical Research Center
Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation.
Chugai Pharmaceutical
Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands.
National Institute of Health Sciences
Synthesis and pharmacological evaluation of novel benzoylazole-based PPARa/κ activators.
Dainippon Sumitomo Pharma
Synthesis and galectin-binding activities of mercaptododecyl glycosides containing a terminalß-galactosyl group.
National Institute of Advanced Industrial Science and Technology (Aist)
Investigation of the histamine H3 receptor binding site. Design and synthesis of hybrid agonists with a lipophilic side chain.
Meiji Seika Kaisha
Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active histamine type 3 receptor agonist and evaluation of its antistress activity in mice.
Meiji Seika Kaisha
Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors.
Banyu Tsukuba Research Institute
BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression.
Takeda Pharmaceutical Co. Ltd.
Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route.
Takeda Pharmaceuticals International
Discovery of a potent and selective alpha v beta 3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model.
Dainippon Pharmaceutical
Design, Synthesis, and Monoamine Oxidase Inhibitory Activity of (+)-Cinchonaminone and Its Simplified Derivatives.
Osaka University
GPIIb/IIIa integrin antagonists with the new conformational restriction unit, trisubstituted beta-amino acid derivatives, and a substituted benzamidine structure.
Nippon Steel
Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1.
Dainippon Pharmaceutical
Structure-activity relations of rosmarinic acid derivatives for the amyloid β aggregation inhibition and antioxidant properties.
Muroran Institute of Technology
4-heteroaryl substituted benzoic acid compounds as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme