118 articles for H Kim
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Cmpds
Data
Article Title
Organization
53
Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design.
Seoul National University
11
Synthetic strategy for increasing solubility of potential FLT3 inhibitor thieno[2,3-d]pyrimidine derivatives through structural modifications at the C
Yonsei University
6
Selective inhibition of monoamine oxidase A by purpurin, an anthraquinone.
Sunchon National University
16
Structural modifications at the 6-position of thieno[2,3-d]pyrimidines and their effects on potency at FLT3 for treatment of acute myeloid leukemia.
Yonsei University
8
Novel JAK1-selective benzimidazole inhibitors with enhanced membrane permeability.
Konkuk University
4
The Halicylindramides, Farnesoid X Receptor Antagonizing Depsipeptides from a Petrosia sp. Marine Sponge Collected in Korea.
Daegu-Gyeongbuk Medical Innovation Foundation
7
Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists.
Yonsei University
2
Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015.
Seoul National University
32
Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization.
Yonsei University
20
Synthesis and biological evaluation of novel thieno[2,3-d]pyrimidine-based FLT3 inhibitors as anti-leukemic agents.
Yonsei University
3
Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl) pyrimidine analogues as selective and potent Raf inhibitors.
Hanyang University
4
Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived Streptomyces sp.
Seoul National University
13
Discovery of thienopyrimidine-based FLT3 inhibitors from the structural modification of known IKKß inhibitors.
Yonsei University
20
Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus.
Yuhan Research Institute
7
Pyrazole-5-carboxamides, novel inhibitors of receptor for advanced glycation end products (RAGE).
Woosuk University
7
Inhibition of Candida albicans isocitrate lyase activity by cadiolides and synoilides from the ascidian Synoicum sp.
Seoul National University
15
Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease.
Korea Institute of Science and Technology
2
Ligand-based design, synthesis, and biological evaluation of 2-aminopyrimidines, a novel series of receptor for advanced glycation end products (RAGE) inhibitors.
Seoul National University
6
Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells.
Hanyang University
25
Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation.
Institute of Science and Technology
10
Design, synthesis, and discovery of stilbene derivatives based on lithospermic acid B as potent protein tyrosine phosphatase 1B inhibitors.
Yonsei University
2
Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1.
TBA
6
Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.
Seoul National University
11
SAR analysis of adenosine diphosphate (hydroxymethyl)pyrrolidinediol inhibition of poly(ADP-ribose) glycohydrolase.
University of Kentucky
7
Syntheses of phenylpyrazolodiazepin-7-ones as conformationally rigid analogs of aminopyrazole amide scaffold and their antiproliferative effects on cancer cells.
Hanyang University
21
Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region.
Deciphera Pharmaceuticals
2
Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line.
Institute of Science and Technology
6
1,4-dihydropyrazolo[4,3-d]imidazole phenyl derivatives: a novel type II Raf kinase inhibitors.
Institute of Science and Technology
16
Tyrosinase-inhibitory constituents from the twigs of Cinnamomum cassia.
Chungnam National University
1
Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.
Duke University
18
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
Decode Biostructures
203
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.
National Cancer Institute-Frederick
22
Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and in vitro and in silico investigations.
Amrita Vishwa Vidyapeetham
1
Effects of Heparan Sulfate Trisaccharide Containing Oleanolic Acid in Attenuating Hyperphosphorylated Tau-Induced Cell Dysfunction Associated with Alzheimer's Disease.
Wayne State University
13
Optimizing Linezolid: Transforming It into a Selective MAO-B Inhibitor via a Toxicity-to-Activity Optimization Approach.
R. C. Patel Institute of Pharmaceutical Education and Research
34
Targeting JNK3 for Alzheimer's disease: Design and synthesis of novel inhibitors with aryl group diversity utilizing wide pocket.
Hanyang University
77
Discovery and Optimization of a Series of Vinyl Sulfoximine-Based Analogues as Potent Nrf2 Activators for the Treatment of Multiple Sclerosis.
Institute of Science & Technology (KIST)
49
Discovery of A-910, a Highly Potent and Orally Bioavailable Dual MerTK/Axl-Selective Tyrosine Kinase Inhibitor.
Abbvie, Inc
10
Synthesis and Biological Evaluation of Peripheral 5HT2B Antagonists for Liver Fibrosis.
Jeonbuk National University Medical School
4
Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader.
Icahn School of Medicine at Mount Sinai
9
Synthesis and Biological Evaluation of Peripheral HTR2A Antagonists for Colorectal Cancer.
Korea Research Institute of Chemical Technology
8
Discovery of novel amidobenzimidazole derivatives as orally available small molecule modulators of stimulator of interferon genes for cancer immunotherapy.
Korea Research Institute of Chemical Technology
35
Discovery of N-(5-amido-2-methylphenyl)-5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability.
Hanyang University
55
Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases.
Hanyang University
42
Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease.
Hanyang University
4
Novel Strategy To Inhibit Transthyretin Amyloidosis via the Synergetic Effect of Chemoselective Acylation and Noncovalent Inhibitor Release.
Chungnam National University
36
Discovery of Novel, Thienopyridine-Based Tyrosine Kinase Inhibitors Targeting Tumorigenic RON Splice Variants.
Wellmarkerbio Co.
6
Synthesis and biological evaluation of xanthine derivatives with phenacyl group as tryptophan hydroxylase 1 (TPH1) inhibitors for obesity and fatty liver disease.
Gwangju Institute of Science and Technology
11
Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions.
Dana-Farber Cancer Institute
5
Carbamate JNK3 Inhibitors Show Promise as Effective Treatments for Alzheimer's Disease: In Vivo Studies on Mouse Models.
Hanyang University
6
Prenylated Chrysin Derivatives as Partial PPARγ Agonists with Adiponectin Secretion-Inducing Activity.
Seoul National University
24
Discovery of a NADPH oxidase inhibitor, (E)-3-cyclohexyl-5-(4-((2-hydroxyethyl)(methyl)amino)benzylidene)-1-methyl-2-thioxoimidazolidin-4-oneone, as a novel therapeutic for Parkinson's disease.
Korea University
35
Discovery of potent indazole-based human glutaminyl cyclase (QC) inhibitors as Anti-Alzheimer's disease agents.
Seoul National University
21
Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor.
Korea Research Institute of Chemical Technology
21
Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators.
Research Institute of Pharmaceutical Sciences
42
2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRPα Checkpoint.
Ewha Womans University
4
Galangin 3-benzyl-5-methylether derivatives function as an adiponectin synthesis-promoting peroxisome proliferator-activated receptor γ partial agonist.
Seoul National University
36
Structure-based discovery and development of novel O-GlcNAcase inhibitors for the treatment of Alzheimer's disease.
Chonnam National University
1
Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size.
National Research Laboratory of Lipid Metabolism and Atherosclerosis
92
Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
Seoul National University
37
A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson's Disease.
Johns Hopkins University School of Medicine
9
Solid-phase synthesis of kojic acid-tripeptides and their tyrosinase inhibitory activity, storage stability, and toxicity.
Seoul National University
1
Further lead optimization on Bax activators: Design, synthesis and pharmacological evaluation of 2-fluoro-fluorene derivatives for the treatment of breast cancer.
University of Texas Medical Branch (Utmb)
3
Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders.
Icahn School Of Medicine At Mount Sinai
2
Sulfamoylbenzamide-based Capsid Assembly Modulators for Selective Inhibition of Hepatitis B Viral Replication.
Korea Research Institute of Chemical Technology
12
Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease.
Gwangju Institute of Science and Technology
7
2-Phenyl-8-(1-phenylallyl)-chromenone compounds have a pan-PPAR modulator pharmacophore.
Seoul National University
19
Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance.
Merck
23
Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
Novartis Institutes For Biomedical Research
10
Design, Synthesis, and Biological Evaluation of New Peripheral 5HT
Gwangju Institute of Science and Technology
14
Discovery of BR102375, a new class of non-TZD PPARγ full agonist for the treatment of type 2 diabetes.
Boryung Pharmaceuticals
14
Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.
Sunchon National University
18
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.
Sunchon National University
3
Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic.
Seoul National University
68
Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer's Agents by Structure-Based Design.
Seoul National University
1
Benzylideneacetone Derivatives Inhibit Osteoclastogenesis and Activate Osteoblastogenesis Independently Based on Specific Structure-Activity Relationship.
Korea University
1
Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer.
University of Texas Medical Branch
2
Bahamaolide A from the marine-derived Streptomyces sp. CNQ343 inhibits isocitrate lyase in Candida albicans.
Seoul National University
2
Potent Hepatitis C Virus NS5A Inhibitors Containing a Benzidine Core.
Seoul National University
23
Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors.
Jeil Pharmaceutical
37
Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities.
Chinese Academy of Sciences
1
Discovery and initial SAR of pyrimidin-4-yl-1H-imidazole derivatives with antiproliferative activity against melanoma cell lines.
Korea Institute of Science and Technology
14
Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers.
Agios Pharmaceuticals
30
First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia.
Korea University
22
Discovery of β-Arrestin Biased Ligands of 5-HT
Korea Institute of Science and Technology
46
Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region.
Seoul National University
12
Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists.
Sogang University
17
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.
Sunchon National University
28
Structure-activity relationship investigation of Phe-Arg mimetic region of human glutaminyl cyclase inhibitors.
Seoul National University
13
Manzamine Alkaloids from an Acanthostrongylophora sp. Sponge.
Seoul National University
1
Discovery of an Orally Bioavailable Benzofuran Analogue That Serves as aβ-Amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer's Disease.
Medifron Dbt
21
MOLECULAR GLUE COMPOUND BASED ON CEREBLON PROTEIN DESIGN AND USE THEREOF
Gluetacs Therapeutics (Shanghai)
57
Indazole compounds as FGFR kinase inhibitor, preparation and use thereof
Shanghai Haihe Pharmaceutical
5
Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives.
Nirma University
9
Specific nNOS inhibitors for the therapy and prevention of human melanoma
Northwestern University
351
Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors
Amgen
25
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]-4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
Abbott Laboratories